ADAM15 Protein (His tag)

Catalog No. ABIN7320075

Product Details

Target: ADAM15 (ADAM Metallopeptidase Domain 15 (ADAM15))

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This ADAM15 protein is labelled with His tag.

Purpose: Recombinant Mouse ADAM15 Protein (His Tag)(Active)

Sequence: Met 1-Thr 697

Characteristics: A DNA sequence encoding the mouse ADAM15 (O88839-1) extracellular domain (Met 1-Thr 697) was expressed, with a C-terminal polyhistidine tag.

Purity: > 90 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: 1. Measured by its ability to bind human PTK6 in a functional ELISA.2. Measured by its ability to bind human SRC in a functional ELISA.3. Measured by its ability to bind mouse SRC in a functional ELISA. 4. Measured by its ability to bind human LYN in a functional ELISA.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: ADAM15 (ADAM Metallopeptidase Domain 15 (ADAM15))

Alternative Name: ADAM15 (ADAM15 Products)

Synonyms: ADAM15 Protein, mdc15 Protein, MDC15 Protein, metargidin Protein, tMDCVI Protein, ADAM metallopeptidase domain 15 Protein, ADAM metallopeptidase domain 15 L homeolog Protein, a disintegrin and metallopeptidase domain 15 (metargidin) Protein, ADAM15 Protein, adam15.L Protein, adam15 Protein, Adam15 Protein

Background:

Background: ADAM15, also known as Metargidin, is a type I transmembrane glycoprotein belonging to the ADAM (A Disintegrin and Metalloprotease Domain) family of proteins and is widely expressed in different tissues and cell types. Members of this family contain an amino-terminal metalloprotease domain followed by a disintegrin domain, a cysteine-rich region and a membrane proximal EGF-like domain. The disintegrin domain of ADAM15/metargidin contains an RGD tripeptide sequence, suggesting that it may potentially interact with the integrin family of proteins. ADAM15 is a transmembrane multi-domain proteins implicated in proteolysis, cell-cell and cell-matrix interactions in various disease conditions. There is also evidence supporting a role for ADAM15 in angiogenesis and angioinvasion of tumor cells, which are critical for unrestrained tumor growth and metastatic spread. Given its diverse functions, ADAM15 may represent a pivotal regulatory component of tumor progression, an important target for therapeutic intervention, or emerge as a biomarker of disease progression.

Synonym: MDC15,metargidin

Molecular Weight: 74.6 kDa