ALDH4A1 Protein (GST tag,His tag)

Catalog No. ABIN7194201

Product Details

Target: ALDH4A1 (Aldehyde Dehydrogenase 4 Family, Member A1 (ALDH4A1))

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Purification tag / Conjugate: This ALDH4A1 protein is labelled with GST tag,His tag.

Purpose: Recombinant Human ALDH4A1 Protein (His & GST Tag)

Sequence: Lys 25-Gln 563

Characteristics: A DNA sequence encoding the mature form of human ALDH4A1 (AAH07581.1) (Lys 25-Gln 563) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Purity: > 80 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.5, 10 % glycerol

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: ALDH4A1 (Aldehyde Dehydrogenase 4 Family, Member A1 (ALDH4A1))

Alternative Name: ALDH4A1 (ALDH4A1 Products)

Synonyms: aldh4 Protein, p5cd Protein, p5cdh Protein, ALDH4 Protein, P5CD Protein, P5CDh Protein, A930035F14Rik Protein, Ahd-1 Protein, Ahd1 Protein, Aldh4 Protein, Aldh5a1 Protein, E330022C09 Protein, P5cd Protein, P5cdh Protein, P5cdhl Protein, P5cdhs Protein, Ssdh1 Protein, zgc:63592 Protein, aldehyde dehydrogenase 4 family member A1 Protein, aldehyde dehydrogenase 4 family, member A1 Protein, aldehyde dehydrogenase 4 family member A1 L homeolog Protein, aldh4a1 Protein, ALDH4A1 Protein, Aldh4a1 Protein, aldh4a1.L Protein

Background:

Background: ALDH4A1 is a member of the aldehyde dehydrogenase family. Aldehyde dehydrogenase enzymes function in the metabolism of many molecules including certain fats (cholesterol and other fatty acids) and protein building blocks (amino acids). Additional aldehyde dehydrogenase enzymes detoxify external substances, such as alcohol and pollutants, and internal substances, such as toxins that are formed within cells. ALDH4A1 is expressed abundantly in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas. It is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Defects in ALDH4A1 are the cause of hyperprolinemia type 2 (HP-2). HP-2 is characterized by the accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. The disorder may be causally related to neurologic manifestations, including seizures and mental retardation.

Synonym: ALDH4,P5CD,P5CDh

Molecular Weight: 86.8 kDa

Pathways: Monocarboxylic Acid Catabolic Process