BMPR1B Protein (AA 149-502) (GST tag,His tag)

Catalog No. ABIN7317106

Product Details

Target: BMPR1B (Bone Morphogenetic Protein Receptor, Type IB (BMPR1B))

Protein Type: Recombinant

Protein Characteristics: AA 149-502

Origin: Human

Source: Baculovirus infected Insect Cells

Purification tag / Conjugate: This BMPR1B protein is labelled with GST tag,His tag.

Purpose: Recombinant Human BMPR1B/ALK-6 Protein (aa 149-502, His&GST Tag)

Sequence: Arg 149-Leu 502

Characteristics: A DNA sequence encoding the human ALK6 (NP_001194.1) cytoplasmic domain (Arg 149-Leu 502) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as sterile 50 mM Tris, 100 mM NaCl, pH 8.5, 20 % glycerol, 0.3 mM DTT

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: BMPR1B (Bone Morphogenetic Protein Receptor, Type IB (BMPR1B))

Alternative Name: BMPR1B/ALK-6 (BMPR1B Products)

Synonyms: ALK6 Protein, BMPR-IB Protein, FecB Protein, alk-6 Protein, alk6 Protein, cdw293 Protein, alk6b Protein, zgc:172219 Protein, BMPR1B Protein, AI385617 Protein, ALK-6 Protein, AV355320 Protein, Acvrlk6 Protein, Alk6 Protein, BMPR-1B Protein, CFK-43a Protein, SKR6 Protein, BR1b Protein, alk6tr Protein, bmpr1b Protein, zALK-6 Protein, zgc:92220 Protein, CDw293 Protein, BMP15 Protein, BMPRIB Protein, RPK-1 Protein, bone morphogenetic protein receptor type 1B Protein, bone morphogenetic protein receptor, type IBb Protein, bone morphogenetic protein receptor, type 1B Protein, bone morphogenetic protein receptor, type IBa Protein, BMPR1B Protein, bmpr1b Protein, bmpr1bb Protein, Bmpr1b Protein, bmpr1ba Protein

Background:

Background: BMPR1B(bone morphogenetic protein receptor, type IB), also known as ALK6, is a a member of the bone morphogenetic protein (BMP) receptor family. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPR1B is the major transducer of signals in precartilaginous condensations as demonstrated in experiments using constitutively active BMPR1B receptors. BMPR1B is a more effective trasducer of GDF5 than BMPR1A. Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.

Synonym: ALK-6,ALK6,CDw293

Molecular Weight: 68.3 kDa

NCBI Accession: NP_001194