BBOX1 Protein (GST tag,His tag)
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- Target See all BBOX1 Proteins
- BBOX1 (butyrobetaine (Gamma), 2-Oxoglutarate Dioxygenase (Gamma-butyrobetaine Hydroxylase) 1 (BBOX1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Baculovirus infected Insect Cells
- Purification tag / Conjugate
- This BBOX1 protein is labelled with GST tag,His tag.
- Purpose
- Recombinant Human BBOX1/Gamma-BBH Protein (His & GST Tag)
- Sequence
- Met 1-Asn387
- Characteristics
- A DNA sequence encoding the human BBOX1 (O75936) (Met1-Asn387) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- Purity
- > 85 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product BBOX1 Protein
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butyrobetaine (Gamma), 2-Oxoglutarate Dioxygenase (Gamma-butyrobetaine Hydroxylase) 1 (BBOX1) (AA 1-387) protein (GST tag)
BBOX1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
butyrobetaine (Gamma), 2-Oxoglutarate Dioxygenase (Gamma-butyrobetaine Hydroxylase) 1 (BBOX1) (AA 278-387) protein (GST tag)BBOX1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
butyrobetaine (Gamma), 2-Oxoglutarate Dioxygenase (Gamma-butyrobetaine Hydroxylase) 1 (BBOX1) protein (Myc-DYKDDDDK Tag)BBOX1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- BBOX1 (butyrobetaine (Gamma), 2-Oxoglutarate Dioxygenase (Gamma-butyrobetaine Hydroxylase) 1 (BBOX1))
- Alternative Name
- BBOX1/Gamma-BBH (BBOX1 Products)
- Synonyms
- BBOX1 Protein, wu:fj14g08 Protein, zgc:112179 Protein, BBH Protein, BBOX Protein, G-BBH Protein, gamma-BBH Protein, Bbh Protein, Bbox Protein, AI874739 Protein, gamma-butyrobetaine hydroxylase 1 Protein, butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 Protein, gamma-butyrobetaine dioxygenase Protein, butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase) Protein, BBOX1 Protein, bbox1 Protein, LOC699465 Protein, Bbox1 Protein
- Background
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Background: BBOX1, also known as gamma-BBH, belongs to the gamma-BBH/TMLD family. It is highly expressed in kidney and moderately expressed in liver. BBOX1 catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. BBOX1 is an inhibition target for mildronate which can be used to treat angina andmyocardial infarction. Mildronate may also be beneficial for the treatment ofneurological disorder, diabetes, and seizures and alcohol intoxication.
Synonym: BBH;BBOX;G-BBH;gamma-BBH
- Molecular Weight
- 72.5 kDa
- UniProt
- O75936
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