BTN1A1 Protein (His tag)

Catalog No. ABIN7320474

Product Details

Target: BTN1A1 (Butyrophilin, Subfamily 1, Member A1 (BTN1A1))

Protein Type: Recombinant

Origin: Mouse

Source: Human Cells

Purification tag / Conjugate: This BTN1A1 protein is labelled with His tag.

Purpose: Recombinant Mouse Butyrophilin 1A1/BTN1A1 Protein (His Tag)

Sequence: Ala27-Trp247

Characteristics: Recombinant Mouse Butyrophilin Subfamily 1 Member A1 is produced by our Mammalian expression system and the target gene encoding Ala27-Trp247 is expressed with a 6His tag at the C-terminus.

Purity: > 95 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: BTN1A1 (Butyrophilin, Subfamily 1, Member A1 (BTN1A1))

Alternative Name: Butyrophilin 1A1/BTN1A1 (BTN1A1 Products)

Synonyms: BT Protein, BTN Protein, Btn Protein, BTN1A1 Protein, TVC Protein, butyrophilin subfamily 1 member A1 Protein, butyrophilin, subfamily 1, member A1 Protein, zgc:162154 Protein, BTN1A1 Protein, Btn1a1 Protein, btn1a1 Protein, zgc:162154 Protein

Background:

Background: Mouse Butyrophilin subfamily 1 member A1(BTN1A1) is a type I transmembrane glycoprotein which is a member of the Ig superfamily. The BTN1A1 ECD displays two predicted IgV and IgC domains as do B7 and Skint proteins which interact with other Ig superfamily members. BTN1A1 binds to xanthine oxidoreductase (XOR). This interaction stabilizes the association of XOR with the milk fat globule membrane and appears to be essential in the control of milk fat globule secretion. In vitro, BTN1A1 inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL-2 and IFN-γ secretion. Furthermore, in vivo, BTN1A1 has a protective effect against the development of experimental autoimmune encephalomyelitis (EAE). Because butyrophilins are structurally related to B7 proteins and are functionally implicated in immune regulation, they may represent an emerging family of costimulatory/inhibitory molecules.

Synonym: Butyrophilin subfamily 1 member A1, BTN, BTN1A1,butyrophilin,Btn1a1

Molecular Weight: 25.4 kDa

UniProt: Q62556

Pathways: Activated T Cell Proliferation