CLEC14A Protein (Fc Tag)

Catalog No. ABIN7321192

Product Details

Target: CLEC14A (C-Type Lectin Domain Family 14, Member A (CLEC14A))

Protein Type: Recombinant

Origin: Rat

Source: HEK-293 Cells

Purification tag / Conjugate: This CLEC14A protein is labelled with Fc Tag.

Purpose: Recombinant Rat CLEC14A/EGFR-5 Protein (Fc Tag)

Sequence: Met1-Thr398

Characteristics: A DNA sequence encoding the rat CLEC14A (Met1-Thr398) was expressed with the Fc region of human IgG1 at the C-terminus.

Purity: (75.4+12.7) % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CLEC14A (C-Type Lectin Domain Family 14, Member A (CLEC14A))

Alternative Name: CLEC14A/EGFR-5 (CLEC14A Products)

Synonyms: C14orf27 Protein, CEG1 Protein, EGFR-5 Protein, 1200003C23Rik Protein, AI642649 Protein, C-type lectin domain containing 14A Protein, C-type lectin domain family 14, member a Protein, CLEC14A Protein, Clec14a Protein

Background:

Background: C-type lectin domain family 14 member A, also known as Epidermal growth factor receptor 5 and CLEC14A, is a member of the C-type lectin domain (CTLD) family that contains one c-type lectin domain and one EGF-like domain. Mouse CLEC14A is a 459 amino acid single-pass type I membrane protein. The superfamily of proteins containing C-type lectin-like domains (CTLDs) is a large group of extracellular Metazoan proteins with diverse functions. The CTLD structure has a characteristic double-loop ('loop-in-a-loop') stabilized by two highly conserved disulfide bridges located at the bases of the loops, as well as a set of conserved hydrophobic and polar interactions. Members of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily share a common fold and are involved in a variety of functions, such as generalized defense mechanisms against foreign agents, discrimination between healthy and pathogen-infected cells, and endocytosis and blood coagulation. Genome-level studies on human, elegans and melanogaster demonstrated almost complete divergence among invertebrate and mammalian families of CTLD-containing proteins (CTLDcps). The vertebrate CTLDcp families were essentially formed early in vertebrate evolution and are completely different from the invertebrate families. The composition of the CTLDcp superfamily in fish and mammals suggests that large scale duplication events played an important role in the evolution of vertebrates.

Synonym: CLEC14A

Molecular Weight: 67.6 kDa

NCBI Accession: NP_001014099