CALCB Protein (Fc Tag)

Catalog No. ABIN7317265

Product Details

Target: CALCB (Calcitonin-Related Polypeptide beta (CALCB))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This CALCB protein is labelled with Fc Tag.

Purpose: Recombinant Human CALCB Protein (aa 1-118, Fc Tag)

Sequence: Met 1-Phe118

Characteristics: A DNA sequence encoding the human CALCB (P10092) (Met1-Phe118) was fused with Fc region of mouse IgG at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CALCB (Calcitonin-Related Polypeptide beta (CALCB))

Alternative Name: CALCB (CALCB Products)

Synonyms: CRSP Protein, CRSP-1 Protein, CRSP1 Protein, CALCB Protein, CALC2 Protein, CGRP-II Protein, CGRP2 Protein, Calc2 Protein, calcitonin-related polypeptide beta Protein, calcitonin related polypeptide beta Protein, calcitonin gene-related peptide 2 Protein, calcitonin-related polypeptide, beta Protein, CALCB Protein, LOC698209 Protein, Calcb Protein

Background:

Background: CALCB, also known as CGPR and calcitonin 2, belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin, blood, and cerebrospinal fluid. CGRP immunolabeling (IL) was detected in epidermal keratinocytes at levels that were especially high and widespread in the skin of humans from locations afflicted with postherpetic neuralgia (PHN) and complex region pain syndrome type 1 (CRPS), of monkeys infected with simian immunodeficiency virus, and of rats subjected to L5/L6 spinal nerve ligation, sciatic nerve chronic constriction, and subcutaneous injection of complete Freund's adjuvant. Increased CGRP-IL was also detected in epidermal keratinocytes of transgenic mice with keratin-14 promoter driven overexpression of noggin, an antagonist to BMP-4 signaling. CGPR dilates a variety of vessels including the coronary, cerebral and systemic vasculature.

Synonym: Calcitonin gene-related peptide 2, CALC2, Beta-type CGRP, Calcitonin gene-related peptide II, CALCB

Molecular Weight: 36.2 kDa

UniProt: P10092

Pathways: Hormone Activity