Calnexin Protein (CANX) (His tag)
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- Target See all Calnexin (CANX) Proteins
- Calnexin (CANX)
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This Calnexin protein is labelled with His tag.
- Purpose
- Recombinant Human Calnexin/CANX Protein (His Tag)
- Sequence
- His21-Pro481
- Characteristics
- Recombinant Human Calnexin is produced by our Mammalian expression system and the target gene encoding His21-Pro481 is expressed with a 6His tag at the C-terminus.
- Purity
- > 85 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product CANX Protein
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Calnexin (CANX) (AA 21-481) protein
CANX Origin: Human Host: Escherichia coli (E. coli) Recombinant SDS
Calnexin (CANX) (AA 504-592) protein (GST tag)CANX Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, 2 mM CaCl, 10 % Glycerol, pH 7.5.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- Calnexin (CANX)
- Alternative Name
- Calnexin/CANX (CANX Products)
- Synonyms
- CNX Protein, IP90 Protein, P90 Protein, 1110069N15Rik Protein, AI988026 Protein, Cnx Protein, D11Ertd153e Protein, canx Protein, clgn Protein, clnx Protein, cnx Protein, PP90 Protein, zgc:63524 Protein, wu:fe06b12 Protein, CANX Protein, calnexin Protein, CalNeXin Protein, calnexin L homeolog Protein, CANX Protein, Canx Protein, cnx-1 Protein, canx.L Protein, canx Protein, LOC100283947 Protein
- Background
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Background: Calnexin/CANX is a single-pass type I membrane protein which belongs to the calreticulin family. It consists of a large N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic tail. The function of calnexin is to retain unfolded or unassembled N-linked glycoproteins in the endoplasmic reticulum. Calnexin is a calcium-binding protein that interacts briefly with newly synthesized glycoproteins in the endoplasmic reticulum. Calnexin may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. Calnexin seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Calnexin dwindles with aging and might contribute to a cytoprotection in an array of human age-related diseases.
Synonym: Calnexin, IP90, Major Histocompatibility Complex Class I Antigen-Binding Protein p88, p90, CANX
- Molecular Weight
- 53.5 kDa
- UniProt
- P27824
- Pathways
- MAPK Signaling, Thyroid Hormone Synthesis
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