CD247 Protein (GST tag)
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- Target See all CD247 Proteins
- CD247 (CD247 Molecule (CD247))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CD247 protein is labelled with GST tag.
- Purpose
- Recombinant Human CD247/CD3-ZETA Protein (GST Tag)
- Sequence
- Arg52-Arg164
- Characteristics
- A DNA sequence encoding the mature form of human CD247 (P20963-1) (Arg52-Arg164) was fused with the GST tag at the N-terminus.
- Purity
- > 92 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CD247 Protein
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CD247 Molecule (CD247) (AA 62-164) protein (His tag)
CD247 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
CD247 Molecule (CD247) (AA 1-164) protein (GST tag)CD247 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
CD247 Molecule (CD247) (AA 52-164) protein (His tag)Crystallography grade CD247 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
CD247 Molecule (CD247) (AA 52-164) protein (His tag)Crystallography grade CD247 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
CD247 Molecule (CD247) (AA 22-164) protein (rho-1D4 tag)Crystallography grade CD247 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
CD247 Molecule (CD247) (AA 22-164) protein (rho-1D4 tag)Crystallography grade CD247 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- CD247 (CD247 Molecule (CD247))
- Alternative Name
- CD247/CD3-ZETA (CD247 Products)
- Synonyms
- CD3-ZETA Protein, CD3H Protein, CD3Q Protein, CD3Z Protein, T3Z Protein, TCRZ Protein, 4930549J05Rik Protein, A430104F18Rik Protein, AW552088 Protein, Cd3 Protein, Cd3-eta Protein, Cd3-zeta Protein, Cd3h Protein, Cd3z Protein, Cd3zeta Protein, T3z Protein, Tcrk Protein, Tcrz Protein, LOC100136514 Protein, LOC100136549 Protein, LOC100305023 Protein, CD247 Protein, TCRzeta Protein, CD247 molecule Protein, CD247 antigen Protein, CD3zeta-2 Protein, CD3zeta-1 Protein, Cd247 molecule Protein, CD247 Protein, Cd247 Protein, cd3z Protein, cd247 Protein
- Background
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Background: CD247, also known as CD3-ZETA, belongs to the CD3Z/FCER1G family. It contains 3 ITAM domains. As a -cell receptor zeta, CD247 forms the T-cell receptor-CD3 complex together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and –epsilon. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for CD247 gene. Defects in CD247 can cause immunodeficiency due to defect in CD3-zeta. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens. CD247 may play a role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
Synonym: CD3-ZETA;CD3H;CD3Q;CD3Z;IMD25;T3Z;TCRZ
- Molecular Weight
- 40.2 kDa
- Pathways
- TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway
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