CD69 Protein (CD69) (AA 64-199) (His tag)

Catalog No. ABIN7319629

Product Details

Target: CD69

Protein Type: Recombinant

Protein Characteristics: AA 64-199

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This CD69 protein is labelled with His tag.

Purpose: Recombinant Human CD69 Protein (aa 64-199, His Tag)

Sequence: Gly64-Lys199

Characteristics: Recombinant Human CD69 is produced by our Mammalian expression system and the target gene encoding Gly64-Lys199 is expressed with a 8His tag at the N-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CD69

Alternative Name: CD69 (CD69 Products)

Synonyms: 5830438K24Rik Protein, AI452015 Protein, AIM Protein, VEA Protein, BL-AC/P26 Protein, CLEC2C Protein, EA1 Protein, GP32/28 Protein, MLR-3 Protein, Cd69 molecule Protein, CD69 antigen Protein, CD69 molecule Protein, Cd69 Protein, CD69 Protein

Background:

Background: Human Early Activation Antigen CD69 (CD69) is a type 2 transmembrane glycoprotein in the C-type lectin family. It plays roles in immune cell trafficking, inflammation, T cell memory, and humoral immune responses. CD69 is expressed on the cell surface as an approximately 60 kDa disulfide-linked homodimer. It is found on CD4+ T cells, CD8+ T cells, NK cells, NKT cells, gamma delta cells dendritic cells (DC) and is up-regulated on activated T cells and DC. Ligation of CD69 on DC induces IL2 production, leading to T cell proliferation. CD69 is important for the homing of CD4+ T cells and plasmablasts to the bone marrow but inhibits the migration of dermal DC to draining lymph nodes. It supports the expression of multiple chemokines and chemokine receptors but suppresses the expression of others. It associates with and negatively regulates S1P1 expression on DC and CD4+ T cells, resulting in a decreased chemotactic response to S1P. The direct interaction of CD69 with Galectin-1 contributes to the ability of CD69 to limit Th17 mediated inflamamtion while supporting the differentiation of regulatory T cells.

Synonym: Early activation antigen CD69, Activation inducer molecule, AIM, BL-AC/P26, C-type lectin domain family 2 member C, EA1, Early T-cell activation antigen p60, GP32/28, Leukocyte surface antigen Leu-23, MLR-3, CD69, CLEC2C

Molecular Weight: 16.9 kDa

UniProt: Q07108