Complement Factor H Protein (CFH) (His tag)
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- Target See all Complement Factor H (CFH) Proteins
- Complement Factor H (CFH)
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- Human Cells
- Purification tag / Conjugate
- This Complement Factor H protein is labelled with His tag.
- Purpose
- Recombinant Mouse Complement Factor H/CFH Protein (His Tag)
- Sequence
- Ser875-Val1252
- Characteristics
- Recombinant Mouse Complement factor H is produced by our Mammalian expression system and the target gene encoding Ser875-Val1252 is expressed with a 6His tag at the C-terminus.
- Purity
- > 90 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product CFH Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl, pH 8.0.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- Complement Factor H (CFH)
- Alternative Name
- Complement Factor H/CFH (CFH Products)
- Synonyms
- AHUS1 Protein, AMBP1 Protein, ARMD4 Protein, ARMS1 Protein, CFHL3 Protein, FH Protein, FHL1 Protein, HF Protein, HF1 Protein, HF2 Protein, HUS Protein, Mud-1 Protein, NOM Protein, Sas-1 Protein, Sas1 Protein, Fh Protein, CFH Protein, im:7147412 Protein, si:ch211-207o17.2 Protein, fH Protein, armd4 Protein, arms1 Protein, cfh Protein, cfhl3 Protein, fhl1 Protein, hf1 Protein, hf2 Protein, hus Protein, complement factor H Protein, complement component factor h Protein, complement factor H-related protein 5 Protein, complement factor H L homeolog Protein, CFH Protein, Cfh Protein, cfh Protein, LOC100399888 Protein, LOC100733902 Protein, cfh.L Protein
- Background
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Background: Complement factor H(CFH) is a 155 kDa glycoprotein that functions as a cofactor in the inactivation of C3b by factor I. It also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway. CFH expressed by the liver and secreted in plasma. This recombinant protein corresponds to SCR15-20 which encompass the primary binding sites for heparin and C3b as well as for the peptide hormone adrenomedullin. Within SCR15-20, mouse Factor H shares 60 % and 80 % amino acid sequence identity with human and rat Factor H, respectively. Dozens of mutations clustered in SCR15-20 are associated with atypical hemolytic uremic syndrome, a disorder characterized by anemia, thrombocytopenia, and renal failure.
Synonym: Complement factor H,Protein beta-1-H,CFH, beta-1-H-globulin
- Molecular Weight
- 43.4 kDa
- UniProt
- E9Q8I0
- Pathways
- Complement System, Cellular Response to Molecule of Bacterial Origin
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