CRLF2 Protein (Fc Tag)

Catalog No. ABIN7319829

Product Details

Target: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This CRLF2 protein is labelled with Fc Tag.

Purpose: Recombinant Human TSLP R/CRLF2 (C-Fc)

Sequence: Gly25-Lys231

Characteristics: Recombinant Human CRLF2 is produced by our Mammalian expression system and the target gene encoding Gly25-Lys231 is expressed with a Fc tag at the C-terminus.

Purity: >95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Loaded Human TSLP-His(Cat#C00K) on HIS1K Biosensor, can bind Human TSLP R-Fc(Cat#CW56) with an affinity constant of 37.97nM as determined in BLI assay.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Alternative Name: TSLP R/CRLF2 (CRLF2 Products)

Synonyms: CRLF2 Protein, CRL2 Protein, CRLF2Y Protein, TSLPR Protein, CRLM2 Protein, Ly114 Protein, Tpte2 Protein, Tslpr Protein, Crl2 Protein, cytokine receptor like factor 2 Protein, cytokine receptor-like factor 2 Protein, CRLF2 Protein, Crlf2 Protein

Background:

Background: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. TSLP R expression is ubiquitous in the immune and hematopoietic cells, but is up-regulated in Th2-skewed cells. Cells expressing TSLP R alone bind TSLP with low affinity. Co-expression of TSLP R and IL-7 R alpha is required for high-affinity TSLP binding and signal transduction . The TSLP R and IL-7 R alpha are coexpressed primarily on monocytes and dendritic cells and at lower levels in lymphoid cells. TSLP has been shown to induce the release of T cell-attracting chemokines from monocytes and enhance the maturation of CD11c+ dendritic cells.

Synonym: CRL2, CRL2cytokine receptor CRL2 precusor, CRLF2, CRLF2Y, CRLM-2, Cytokine receptor-like 2,cytokine receptor-like factor 2, ILXR, IL-XR, P2RY8/CRLF2 fusion, PCOR1, TSLP R, TSLP receptor,TSLPR

Molecular Weight: 50.9 kDa

UniProt: Q9HC73