Dual Specificity Phosphatase 3 (DUSP3) protein (His tag)
Quick Overview for Dual Specificity Phosphatase 3 (DUSP3) protein (His tag) (ABIN7319414)
Target
See all Dual Specificity Phosphatase 3 (DUSP3) ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- His tag
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Purpose
- Recombinant Human DUSP3/VHR Protein (His Tag)
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Sequence
- Ser2-Pro185
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Characteristics
- Recombinant Human DUSP3 is produced by our E.coli expression system and the target gene encoding Ser2-Pro185 is expressed with a 6His tag at the N-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Dual Specificity Phosphatase 3 (DUSP3) (AA 1-185) protein (His tag)
custom-made DUSP3 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Dual Specificity Phosphatase 3 (DUSP3) (AA 1-185) protein (His tag)custom-made DUSP3 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Dual Specificity Phosphatase 3 (DUSP3) (AA 1-185) protein (GST tag)DUSP3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Dual Specificity Phosphatase 3 (DUSP3) (AA 1-144) protein (GST tag)DUSP3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Dual Specificity Phosphatase 3 (DUSP3) (AA 1-205) protein (His-IF2DI Tag)DUSP3 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Dual Specificity Phosphatase 3 (DUSP3) (AA 1-185) (Active) protein (His tag)DUSP3 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % SDS, EAA Active
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Restrictions
- For Research Use only
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Format
- Frozen, Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Dual Specificity Phosphatase 3 (DUSP3)
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Alternative Name
- DUSP3/VHR
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Target Type
- Viral Protein
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Background
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Background: Human DUSP3 belongs to the dual specificity protein phosphatase subfamily. DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs are major modulators of critical signalling pathways that are dysregulated in various diseases. They negatively regulate members of the mitogen-activated protein kinase superfamily, which are associated with cellular proliferation and differentiation. DUSP3 is expressed in human tissues including breast and ovarian.DUSP3 shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Human DUSP3 specifically dephosphorylates and inactivates ERK1 and ERK2.
Synonym: Dual specificity protein phosphatase 3,DUSP3,Dual specificity protein phosphatase VHR,Vaccinia H1-related phosphatase,VHR
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Molecular Weight
- 22.6 kDa
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UniProt
- P51452
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Pathways
- Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
Target
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