FZD1 Protein (His tag)

Catalog No. ABIN7195855

Product Details

Target: FZD1 (Fzd1) (Frizzled Family Receptor 1 (Fzd1))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This FZD1 protein is labelled with His tag.

Purpose: Recombinant Mouse Frizzled 1/FZD1 Protein (His Tag)

Sequence: Met 1-His 248

Characteristics: A DNA sequence encoding the mouse FZD1 (NP_067432.2) extracellular domain (Met 1-His 248) was expressed with a polyhistidine tag at the C-terminus.

Purity: > 97 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: FZD1 (Fzd1) (Frizzled Family Receptor 1 (Fzd1))

Alternative Name: Frizzled 1/FZD1 (Fzd1 Products)

Synonyms: CG17697 Protein, CG3646 Protein, DFZ1 Protein, DFz Protein, DFz1 Protein, Dfz1 Protein, Dm Fz1 Protein, Dmel\\CG17697 Protein, FZ Protein, Frz Protein, Fz Protein, Fz1 Protein, frz Protein, fz1 Protein, fz[[1]] Protein, Fz-1 Protein, cFz-1 Protein, Xfrizzled-1 Protein, frizzled1 Protein, frz-1 Protein, frz1 Protein, fzd1-A Protein, AW227548 Protein, FZ-1 Protein, frizzled Protein, frizzled class receptor 1 Protein, frizzled class receptor 1 L homeolog Protein, fz Protein, FZD1 Protein, Fzd1 Protein, fzd1.L Protein

Background:

Background: Frizzled-1, also known as FZD1, belongs to the G-protein coupled receptor Fz/Smo family. FZD1 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. FZD1 is expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. Frizzled is a family of G protein-coupled receptor proteins that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol. Frizzled proteins and the genes encoding them have been identified in an array of animals, from sponges to humans. Frizzled proteins play key roles in governing cell polarity, embryonic development, formation of neural synapses, cell proliferation, and many other processes in developing and adult organisms. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.

Synonym: Frizzled-1; Fz-1; mFz1; Fzd1; Frizzled homolog 1

Molecular Weight: 21 kDa

NCBI Accession: NP_067432

Pathways: WNT Signaling, Asymmetric Protein Localization