FZD1 Protein (Fc Tag,His tag)

Catalog No. ABIN7534554

Product Details

Target: FZD1 (Fzd1) (Frizzled Family Receptor 1 (Fzd1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This FZD1 protein is labelled with Fc Tag,His tag.

Purpose: Recombinant Human Frizzled-1/FZD1 Protein

Sequence: QAAGQGPGQG PGPGQQPPPP PQQQQSGQQY NGERGISVPD HGYCQPISIP LCTDIAYNQT IMPNLLGHTN QEDAGLEVHQ FYPLVKVQCS AELKFFLCSM YAPVCTVLEQ ALPPCRSLCE RARQGCEALM NKFGFQWPDT LKCEKFPVHG AGELCVGQNT SDKGTPTPSL LPEFWTSNPQ H

Specificity: Gln73-His253

Purity: > 92 % by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: < 0.1 EU/μg of the protein by LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Storage: -20 °C,-80 °C

Storage Comment: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Target Details

Target: FZD1 (Fzd1) (Frizzled Family Receptor 1 (Fzd1))

Alternative Name: Frizzled-1/FZD1 (Fzd1 Products)

Synonyms: CG17697 Protein, CG3646 Protein, DFZ1 Protein, DFz Protein, DFz1 Protein, Dfz1 Protein, Dm Fz1 Protein, Dmel\\CG17697 Protein, FZ Protein, Frz Protein, Fz Protein, Fz1 Protein, frz Protein, fz1 Protein, fz[[1]] Protein, Fz-1 Protein, cFz-1 Protein, Xfrizzled-1 Protein, frizzled1 Protein, frz-1 Protein, frz1 Protein, fzd1-A Protein, AW227548 Protein, FZ-1 Protein, frizzled Protein, frizzled class receptor 1 Protein, frizzled class receptor 1 L homeolog Protein, fz Protein, FZD1 Protein, Fzd1 Protein, fzd1.L Protein

Background:

Description: This protein belongs to the G-protein coupled receptor Fz/Smo family. FZD1 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. FZD1 is expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. Frizzled is a family of G protein-coupled receptor proteins that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol. Frizzled proteins and the genes encoding them have been identified in an array of animals, from sponges to humans. Frizzled proteins play key roles in governing cell polarity, embryonic development, formation of neural synapses, cell proliferation, and many other processes in developing and adult organisms. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.

Name: FZD1

Gene ID: 8321

UniProt: Q9UP38

Pathways: WNT Signaling, Asymmetric Protein Localization