FZD10 Protein (Fc Tag)

Catalog No. ABIN7195856

Product Details

Target: FZD10 (Frizzled Family Receptor 10 (FZD10))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This FZD10 protein is labelled with Fc Tag.

Purpose: Recombinant Mouse Frizzled-10/FZD10 Protein (Fc Tag)

Sequence: Met 1-Gly 162

Characteristics: A DNA sequence encoding the N-terminal segment of mouse FZD10 (NP_780493.1) (Met 1-Gly 162) was fused with the Fc region of human IgG1 at the C-terminus.

Purity: > 90 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: FZD10 (Frizzled Family Receptor 10 (FZD10))

Alternative Name: Frizzled-10/FZD10 (FZD10 Products)

Synonyms: CD350 Protein, FZ-10 Protein, Fz10 Protein, FzE7 Protein, hFz10 Protein, cFz-10 Protein, Fz-10 Protein, Xfr9 Protein, Xfz10 Protein, frizzled-10 Protein, frizzled10 Protein, fz10 Protein, fze7 Protein, hfz10 Protein, fk48e04 Protein, fz4 Protein, fzb Protein, wu:fk48e04 Protein, zg04 Protein, Xfz10A Protein, fzd10a Protein, Xfz10B Protein, Xfz9 Protein, fzd10b Protein, fzd9 Protein, frizzled class receptor 10 Protein, frizzled class receptor 10 L homeolog Protein, frizzled class receptor 10 S homeolog Protein, FZD10 Protein, fzd10 Protein, Fzd10 Protein, fzd10.L Protein, fzd10.S Protein

Background:

Background: Frizzled-10, also known as Fz-10, CD350 and FZD10, is a multi-pass membrane protein which belongs to the G-protein coupled receptor Fz/Smo family. Frizzled-10 / FZD10 is abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. It is weakly expressed in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate. Frizzled-10 / FZD10 is a receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Frizzled-10 / FZD10 may also be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Synonym: Fz-10

Molecular Weight: 43 kDa

NCBI Accession: NP_780493

Pathways: WNT Signaling