IGFBP5 Protein (His tag)

Catalog No. ABIN7320561

Product Details

Target: IGFBP5 (Insulin-Like Growth Factor Binding Protein 5 (IGFBP5))

Protein Type: Recombinant

Origin: Mouse

Source: Human Cells

Purification tag / Conjugate: This IGFBP5 protein is labelled with His tag.

Purpose: Recombinant Mouse IGFBP-5/IGFBP5 Protein (His Tag)

Sequence: Leu20-Glu271

Characteristics: Recombinant Mouse Insulin-like growth factor-binding protein 5 is produced by our Mammalian expression system and the target gene encoding Leu20-Glu271 is expressed with a 6His tag at the C-terminus.

Purity: > 90 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: IGFBP5 (Insulin-Like Growth Factor Binding Protein 5 (IGFBP5))

Alternative Name: IGFBP-5/IGFBP5 (IGFBP5 Products)

Synonyms: IBP5 Protein, AI256729 Protein, AW208790 Protein, IGFBP-5 Protein, IGFBP-5P Protein, IGF-BP5 Protein, igfbp5 Protein, ibp5 Protein, IBP-5 Protein, xIGFBP-5 Protein, IGFBP5 Protein, igfbp5b Protein, zgc:165472 Protein, insulin like growth factor binding protein 5 Protein, insulin-like growth factor binding protein 5 Protein, insulin like growth factor binding protein 5 L homeolog Protein, insulin-like growth factor binding protein 5b Protein, insulin-like growth factor-binding protein 5 Protein, insulin-like growth factor binding protein 5a Protein, IGFBP5 Protein, Igfbp5 Protein, igfbp5.L Protein, igfbp5b Protein, igfbp5 Protein, LOC100194500 Protein, igfbp5a Protein

Background:

Background: Mouse Insulin-like growth factor-binding protein 5(IGFBP-5) belongs to the superfamily of insulin-like growth factor (IGF) binding proteins. It contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. Mouse IGFBP-5 shows 97 % aa sequence identity with those of human and rat IGFBP-5. It is expressed mostly in kidney, uterus and gastrocnemius muscle. It also expressed by fibroblasts, myoblasts and osteoblasts, making it the predominant IGFBP found in bone extracts. IGFBP-5 has a strong affinity for hydroxyapatite, allowing it to bind to bone cells. When bound to extracelluar matrix, IGFBP-5 is protected from proteolysis and potentiates IGF activity, but when it is soluble, IGFBP-5 is cleaved to a biologically inactive 21 kDa fragment. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Synonym: BP-5, IGFBP-5, IGF-binding protein 5, Insulin-like growth factor-binding protein 5,

Molecular Weight: 29.3 kDa

UniProt: Q07079

Pathways: WNT Signaling, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding