IL22RA2 Protein (His tag)
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- Target See all IL22RA2 Proteins
- IL22RA2 (Interleukin 22 Receptor, alpha 2 (IL22RA2))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IL22RA2 protein is labelled with His tag.
- Purpose
- Recombinant Human IL-22BP/IL22RA2 Protein (His Tag)(Active)
- Sequence
- Met 1-Pro 231
- Characteristics
- A DNA sequence encoding the human IL22RA2 isoform 2 (NP_851826.1) (Met 1-Pro 231) was expressed, fused with a polyhistidine tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Immobilized IL22BP-His at 10 μg/ml (100 μl/well) can bind biotinylated IL22, The EC50 of biotinylated IL22 is 1.78-4.14 ng/ml.
- Top Product
- Discover our top product IL22RA2 Protein
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Interleukin 22 Receptor, alpha 2 (IL22RA2) (AA 22-231) protein (His tag)
IL22RA2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 22 Receptor, alpha 2 (IL22RA2) (AA 22-263) protein (His tag)Crystallography grade IL22RA2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Interleukin 22 Receptor, alpha 2 (IL22RA2) (AA 21-230) protein (His tag)Crystallography grade IL22RA2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- IL22RA2 (Interleukin 22 Receptor, alpha 2 (IL22RA2))
- Alternative Name
- IL-22BP/IL22RA2 (IL22RA2 Products)
- Synonyms
- CRF2-10 Protein, CRF2-S1 Protein, CRF2X Protein, IL-22BP Protein, IL-22R-alpha-2 Protein, IL-22RA2 Protein, ZCYTOR16 Protein, CRF2-s1 Protein, Il-22bp Protein, Crf2-s1 Protein, interleukin 22 receptor subunit alpha 2 Protein, interleukin 22 receptor, alpha 2 Protein, IL22RA2 Protein, Il22ra2 Protein
- Background
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Background: Interleukin-22 receptor subunit alpha-2 (IL-22RA2), also known as interleukin-22-binding protein (IL-22BP), is a subunit of the receptor for interleukin 22. IL-22BP belongs to the type I I cytokine receptor family and contains 3 fibronectin type-III domains. IL-22BP/IL-22RA2 is expressed in a range of tissues, including those in the digestive, female reproductive, and immune systems. It is expressed in placenta, spleen, breast, skin and lung. It is also detected in intestinal tract, testis, brain, heart and thymus. The dominant cell types expressing IL-22BP/IL-22RA2 were mononuclear cells and epithelium. IL-22BP/IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important roles in immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptor have been discovered, a membrane-bound receptor and a soluble receptor.
Synonym: CRF2-10,CRF2-S1,CRF2X,IL-22BP,IL-22R-alpha-2,IL-22RA2,ZCYTOR16
- Molecular Weight
- 26.1 kDa
- NCBI Accession
- NP_851826
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