IL22RA2 Protein (His tag)
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- Target See all IL22RA2 Proteins
- IL22RA2 (Interleukin 22 Receptor, alpha 2 (IL22RA2))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IL22RA2 protein is labelled with His tag.
- Purpose
- Active Recombinant Human IL-22RA2/IL22BP Protein
- Sequence
- TQSTHESLKP QRVQFQSRNF HNILQWQPGR ALTGNSSVYF VQYKIYGQRQ WKNKEDCWGT QELSCDLTSE TSDIQEPYYG RVRAASAGSY SEWSMTPRFT PWWETKIDPP VMNITQVNGS LLVILHAPNL PYRYQKEKNV SIEDYYELLY RVFIINNSLE KEQKVYEGAH RAVEIEALTP HSSYCVVAEI YQPMLDRRSQ RSEERCVEIP
- Specificity
- Thr22-Pro231
- Purity
- > 90 % by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- < 0.1 EU/μg of the protein by LAL method.
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized recombinant Human IL22 at 2 μg/mL (100 μL/well) can bind recombinant Human IL22BP, the EC50 of Human IL22BP is 10.78 ng/mL.
- Top Product
- Discover our top product IL22RA2 Protein
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Interleukin 22 Receptor, alpha 2 (IL22RA2) (AA 22-231) protein (His tag)
IL22RA2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 22 Receptor, alpha 2 (IL22RA2) (AA 22-263) protein (His tag)Crystallography grade IL22RA2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Interleukin 22 Receptor, alpha 2 (IL22RA2) (AA 21-230) protein (His tag)Crystallography grade IL22RA2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- Buffer
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- Storage
- -20 °C,-80 °C
- Storage Comment
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Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
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- Target
- IL22RA2 (Interleukin 22 Receptor, alpha 2 (IL22RA2))
- Alternative Name
- IL-22RA2/IL22BP (IL22RA2 Products)
- Synonyms
- CRF2-10 Protein, CRF2-S1 Protein, CRF2X Protein, IL-22BP Protein, IL-22R-alpha-2 Protein, IL-22RA2 Protein, ZCYTOR16 Protein, CRF2-s1 Protein, Il-22bp Protein, Crf2-s1 Protein, interleukin 22 receptor subunit alpha 2 Protein, interleukin 22 receptor, alpha 2 Protein, IL22RA2 Protein, Il22ra2 Protein
- Background
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Description: Interleukin 22 binding protein (IL-22BP), also known as CRF2-10, CRF2-X, and IL-22RA2, is a 35-45 kDa secreted glycoprotein in the type II cytokine receptor family (CRF). IL-22BP specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor.IL-22BP is produced by dendritic cells (DC), epithelial cells, activated B cells, and activated monocytes. It is constitutively expressed by DC but is down-regulated during local inflammation and in response to tissue damage. IL-22BP is critical for limiting IL-22 induced epithelial cell proliferation during wound healing, and its deficiency can enable uncontrolled proliferation and enhance tumor development.
Name: IL22RA2,CRF2-10,CRF2-S1,CRF2X,IL-22BP,IL-22R-alpha-2,IL-22RA2,ZCYTOR16
- Gene ID
- 116379
- UniProt
- Q969J5-2
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