MAPKSP1 Protein (His tag)
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- Target See all MAPKSP1 Proteins
- MAPKSP1 (Mitogen-Activated Protein Kinase Kinase 1 Interacting Protein 1 (MAPKSP1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This MAPKSP1 protein is labelled with His tag.
- Purpose
- Recombinant Human LAMTOR3/MP1 Protein (His Tag)
- Sequence
- Met 1-Val124
- Characteristics
- Recombinant Human Mitogen-Activated Protein Kinase Scaffold Protein 1 is produced by our E.coli expression system and the target gene encoding Met1-Val124 is expressed with a 6His tag at the N-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product MAPKSP1 Protein
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 100 mM NaCl, 5 mM DTT, 30 % Glycerol, pH 8.0.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- MAPKSP1 (Mitogen-Activated Protein Kinase Kinase 1 Interacting Protein 1 (MAPKSP1))
- Alternative Name
- LAMTOR3/MP1 (MAPKSP1 Products)
- Synonyms
- MAPKSP1 Protein, MAP2K1IP1 Protein, MAPBP Protein, MP1 Protein, PRO0633 Protein, Ragulator3 Protein, AW556229 Protein, Map2k1ip1 Protein, Mapbp Protein, Mapksp1 Protein, Mp1 Protein, mapksp1 Protein, zgc:110207 Protein, late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Protein, LAMTOR3 Protein, Lamtor3 Protein, lamtor3 Protein
- Background
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Background: Mitogen-Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) was identified as an interacting protein that belongs to the LAMTOR3 family. MAPKSP1 restricted to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. MAPKSP1 interacts with MAP2K1/MEK1 and MAPK2 and enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade.
Synonym: Ragulator Complex Protein LAMTOR3, Late Endosomal/Lysosomal Adaptor and MAPK and MTOR Activator 3, MEK-Binding Partner 1, Mp1, Mitogen-Activated Protein Kinase Kinase 1-Interacting Protein 1, Mitogen-Activated Protein Kinase Scaffold Protein 1, LAMTOR3, MAP2K1IP1, MAPKSP1
- Molecular Weight
- 15.8 kDa
- UniProt
- Q9UHA4
- Pathways
- PI3K-Akt Signaling
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