NAALADL1 Protein (His tag)

Catalog No. ABIN7317641

Product Details

Target: NAALADL1 (N-Acetylated alpha-Linked Acidic Dipeptidase-Like 1 (NAALADL1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This NAALADL1 protein is labelled with His tag.

Purpose: Recombinant Human NAALADL1 Protein (His Tag)

Sequence: Pro 29-Leu 740

Characteristics: A DNA sequence encoding the extracellular domain of human NAALADL1 (NP_005459.2) (Pro 29-Leu 740) was expressed, with a polyhistidine tag at the N-terminus.

Purity: > 97 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: NAALADL1 (N-Acetylated alpha-Linked Acidic Dipeptidase-Like 1 (NAALADL1))

Alternative Name: NAALADL1 (NAALADL1 Products)

Synonyms: I100 Protein, NAALADASEL Protein, Gm964 Protein, Naaladasel Protein, N-acetylated alpha-linked acidic dipeptidase like 1 Protein, N-acetylated alpha-linked acidic dipeptidase-like 1 Protein, NAALADL1 Protein, Naaladl1 Protein

Background:

Background: N-acetylated-alpha-linked acidic dipeptidase-like protein, also known as NAALADL1, NAALADase L, and Ileal dipeptidylpeptidase, is a Single-pass type I I membrane protein and a member of the peptidase M28 family and M28B subfamily. NAALADase L is mainly expressed in the distal small intestine. It is also expressed in the spleen and testis and Weakly expressed in the brain, locating mainly to the brain stem, amygdala, thalamus and ventral striatum. NAALADase L is a chloride-activated, membrane bound, metallopeptidase that cleaves the endogenous neuropeptide N-acetyl-aspartyl-glutamate (NAAG). NAAG acts as a partial NMDA agonist as well as a full agonist at the presynaptic metabotropic glutamate receptor 3 (mGluR3), where it acts to reduce glutamate release. NAALADase L also exhibits a dipeptidyl-peptidase IV type activity. NAALADase inhibition may be a novel therapeutic approach to reduce or inhibit heightened aggressiveness, and possibly to treat aggressive behavior associated with psychiatric disorders.

Synonym: I100,NAALADASEL,NAALADL1

Molecular Weight: 80 kDa

NCBI Accession: NP_005459