NFATC4 Protein (His tag)

Catalog No. ABIN7319936

Product Details

Target: NFATC4 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 4 (NFATC4))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This NFATC4 protein is labelled with His tag.

Purpose: Recombinant Human NFATC4 protein (His Tag)

Sequence: 401S-683F

Characteristics: A DNA sequence encoding the Human NFATC4 (Q14934-1) (401S-683F) was expressed with a polyhistidine tag at the N-terminus.

Purity: >95 % as determined by reducing SDS-PAGE.

Biological Activity Comment: Immunogen(E-AB-40328)

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as sterile Tris,EDTA,PH 8.0.

Storage: -20 °C,-80 °C

Storage Comment: Samples are stable for up to twelve months from date of receipt at -70°C.Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Target Details

Target: NFATC4 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 4 (NFATC4))

Alternative Name: NFATC4 (NFATC4 Products)

Synonyms: si:dkeyp-66d1.4 Protein, NFATC4 Protein, 3110041H08Rik Protein, AW107667 Protein, AW546455 Protein, Nfat3 Protein, NF-ATc4 Protein, NFAT3 Protein, nuclear factor of activated T-cells 4 Protein, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 Protein, nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 Protein, NFATC4 Protein, nfatc4 Protein, Nfatc4 Protein

Background:

Background: Ca2+-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4. Along with NFATC3, involved in embryonic heart development. Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function. Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC. Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival. Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) . Plays a role in adipocyte differentiation. May be involved in myoblast differentiation into myotubes. Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription. Binds to PPARG gene promoter and regulates its activity. Binds to PPARG and REG3G gene promoters.

Synonym: cytoplasmic 4, NF ATc4, NF-AT3, NF-ATc4, NFAC4_HUMAN, NFAT3, NFATc4, Nuclear factor of activated T cells cytoplasmic 4, Nuclear factor of activated T cells cytoplasmic calcineurin dependent 4, Nuclear factor of activated T-cells, T cell transcription factor NFAT3, T-cell transcription factor NFAT3

Molecular Weight: 31.5kDa

Pathways: RTK Signaling, WNT Signaling