Osteoactivin Protein (GPNMB) (His tag)

Catalog No. ABIN7320265

This Recombinant Osteoactivin protein is expressed in HEK-293 Cells.

Quick Overview for Osteoactivin Protein (GPNMB) (His tag) (ABIN7320265)

Target: Osteoactivin (GPNMB)

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This Osteoactivin protein is labelled with His tag.

Purpose: Recombinant Mouse GPNMB/Osteoactivin Protein (His Tag)

Sequence: Met1-Asn502

Characteristics: A DNA sequence encoding the mouse GPNMB (Q99P91) (Met1-Asn502) was expressed with a C-terminal polyhistidine tag.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Osteoactivin (GPNMB)

Alternative Name: GPNMB/Osteoactivin

Background:

Background: GPNMB belongs to the PMEL / NMB family, also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ), is a transmembrane glycoprotein that is expressed in numerous cells, including osteoclasts, macrophages, dendritic cells, and tumor cells. It is suggested to influence osteoblast maturation, cell adhesion and migration. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages. Osteoactivin is expressed at high levels in normal and inflammatory liver macrophages suggesting a significant role in acute liver injury. The early-phase upregulation of Osteoactivin expression in the tubular epithelium in response to renal injury might play a role in triggering renal interstitial fibrosis via activation of matrix metalloproteinase expression and collagen remodeling in rats. Osteoactivin as a protein that is expressed in aggressive human breast cancers and is capable of promoting breast cancer metastasis to bone.

Synonym: DC-HIL,Dchil,ipd

Molecular Weight: 54.9 kDa

UniProt: Q99P91