OLR1 Protein (AA 61-273) (His tag)

Catalog No. ABIN7275197

Product Details

Target: OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))

Protein Type: Recombinant

Protein Characteristics: AA 61-273

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This OLR1 protein is labelled with His tag.

Purpose: Human LOX1 Protein

Sequence: Ser61-Gln273

Characteristics: Recombinant Human LOX1 Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Ser61-Gln273.

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))

Alternative Name: LOX1 (OLR1 Products)

Synonyms: OLR1 Protein, LOX1 Protein, Olr1 Protein, CLEC8A Protein, LOXIN Protein, SCARE1 Protein, SLOX1 Protein, LOX-1 Protein, SR-EI Protein, Scare1 Protein, Oldlr1 Protein, Oldr1 Protein, PLOX-1 Protein, oxidized low density lipoprotein receptor 1 Protein, oxidized low density lipoprotein (lectin-like) receptor 1 Protein, OLR1 Protein, Olr1 Protein

Background: LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL.LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion also results in damage from ischemia, making LOX-1 a promising target of therapy for atherosclerosis and related disorders. In this article we focus on the different mechanisms for regulation, signaling and the various effects of LOX-1 in contributing to atherosclerosis.

Molecular Weight: 25.4 kDa. Due to glycosylation, the protein migrates to 30-36 kDa based on Tris-Bis PAGE result.