PDIA6 Protein (His tag)

Catalog No. ABIN7318952

Product Details

Target: PDIA6 (Protein Disulfide Isomerase Family A, Member 6 (PDIA6))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This PDIA6 protein is labelled with His tag.

Purpose: Recombinant Human PDIA6 Protein (His Tag)

Sequence: Leu20-Leu440

Characteristics: Recombinant Human Protein Disulfide-Isomerase A6 is produced by our Mammalian expression system and the target gene encoding Leu20-Leu440 is expressed with a 6His tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, 10 % Glycerol, pH 8.0.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: PDIA6 (Protein Disulfide Isomerase Family A, Member 6 (PDIA6))

Alternative Name: PDIA6 (PDIA6 Products)

Synonyms: 1700015E05Rik Protein, AL023058 Protein, C77895 Protein, CaBP5 Protein, P5 Protein, Txndc7 Protein, ERP5 Protein, TXNDC7 Protein, CaBP1 Protein, pdi-p5 Protein, erp5 Protein, pdia6 Protein, pdip5 Protein, txndc7 Protein, protein disulfide isomerase family A member 6 Protein, protein disulfide isomerase associated 6 Protein, protein disulfide isomerase family A, member 6 Protein, protein disulfide isomerase family A member 6 L homeolog Protein, PDIA6 Protein, Pdia6 Protein, pdia6.L Protein

Background:

Background: Protein Disulfide-Isomerase A6 (PDIA6) is a 48.5 kDa protein that belongs to the protein disulfide isomerase family (PDI). PDIA6 is an enzyme in the endoplasmic reticulum in eukaryotes which catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. The PDIA6 expressed in platelets, its functions as a chaperone that inhibits aggregation of misfolded proteins. PDIA6 is part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1. PDIA6 also plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.

Synonym: Protein Disulfide-Isomerase A6, Endoplasmic Reticulum Protein 5, ER Protein 5, ERp5, Protein Disulfide Isomerase P5, Thioredoxin Domain-Containing Protein 7, PDIA6, ERP5, P5, TXNDC7

Molecular Weight: 47.2 kDa

UniProt: Q15084

Pathways: ER-Nucleus Signaling, Cell RedoxHomeostasis