PTPMT1 Protein (His tag)

Catalog No. ABIN7317331

Product Details

Target: PTPMT1 (Protein Tyrosine Phosphatase, Mitochondrial 1 (PTPMT1))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This PTPMT1 protein is labelled with His tag.

Purpose: Recombinant Human PTPMT1 Protein (His Tag)(Active)

Sequence: Lys 28-Thr 201

Characteristics: A DNA sequence encoding the human PTPMT1 isoform 1 (Q8WUK0-1) (Lys 28-Thr 201) was expressed, with a polyhistidine tag at the N-terminus.

Purity: > 94 % as determined by reducing SDS-PAGE.

Biological Activity Comment: Measured by its ability to cleave pNPP.The specific activity is >200 pmoles/min/μg.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, 10 % glycerol, 1 mM DTT, pH 7.5

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: PTPMT1 (Protein Tyrosine Phosphatase, Mitochondrial 1 (PTPMT1))

Alternative Name: PTPMT1 (PTPMT1 Products)

Synonyms: im:7137979 Protein, zgc:158719 Protein, DUSP23 Protein, MOSP Protein, PLIP Protein, 1110001D10Rik Protein, 2810004N20Rik Protein, Plip Protein, protein tyrosine phosphatase, mitochondrial 1 Protein, PTPMT1 Protein, ptpmt1 Protein, Ptpmt1 Protein

Background:

Background: PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion. It has been recently reported that PTPMT1 dephosphorylates phosphatidylglycerol phosphate, an essential intermediate of cardiolipin biosynthesis. PTPMT1 deficiency in mouse embryonic fibroblasts compromises mitochondrial respiration and results in abnormal mitochondrial morphology. Lipid analysis of PTPMT1-deficient fibroblasts reveals an accumulation of PGP along with a concomitant decrease in phosphatidylglycerol. Modulation of mitochondrial ATP synthesis by PTPMT1 suggests a novel approach for the treatment of pancreatic cancers, which represent some of the deadliest forms of human tumors. The gluttony of cancer cells for energy is well established, and with the development of a modulator of expression, one may hope that we could also achieve the synthetic induction of PTPMT1 expression. It would then be expected that this effect would attenuate, if not abolish, the growth of pancreas-derived tumor cells and support the establishment of a novel regimen for pancreatic cancers. 

Synonym: DUSP23;FLJ46081;MOSP;PLIP;PNAS-129

Molecular Weight: 21.7 kDa

Pathways: Inositol Metabolic Process