PTPN2 Protein (His tag)

Catalog No. ABIN7319874

Product Details

Target: PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This PTPN2 protein is labelled with His tag.

Purpose: Recombinant Human TC-PTP/PTPN2 (C-6His)

Sequence: Thr2-Asn314

Characteristics: Recombinant Human Tyrosine-protein phosphatase non-receptor type 2 is produced by our E.coli expression system and the target gene encoding Thr2-Asn314 is expressed with a 6His tag at the C-terminus.

Purity: >95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM HEPES, 300Mm NaCl, 1 mM DTT, 10 % Glycerol, pH 7.4.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))

Alternative Name: TC-PTP/PTPN2 (PTPN2 Products)

Synonyms: PTN2 Protein, PTPT Protein, TC-PTP Protein, TCELLPTP Protein, TCPTP Protein, AI325124 Protein, Ptpt Protein, PTP-1B Protein, cb806 Protein, ptpn2 Protein, ptpn2l Protein, wu:fc10h07 Protein, zgc:55339 Protein, zgc:76973 Protein, hm:zeh1546 Protein, zgc:63623 Protein, ptn2 Protein, ptpt Protein, tc-ptp Protein, tcellptp Protein, tcptp Protein, protein tyrosine phosphatase, non-receptor type 2 Protein, protein tyrosine phosphatase, non-receptor type 2 S homeolog Protein, protein tyrosine phosphatase, non-receptor type 2, b Protein, protein tyrosine phosphatase, non-receptor type 2, a Protein, protein tyrosine phosphatase, non-receptor type 2 L homeolog Protein, PTPN2 Protein, Ptpn2 Protein, ptpn2.S Protein, ptpn2b Protein, ptpn2a Protein, ptpn2.L Protein

Background:

Background: Tyrosine-protein phosphatase non-receptor type 2 (PTPN2), also known as PTPT and TC-PTP, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. Members of the protein tyrosine phosphatase ( PTP ) family share a highly conserved catalytic motif, which is essential for the catalytic activity. TC-PTP / PTPN2 is a cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins. The expression of TC-PTP / PTPN2 plays a role of tumor suppressor and may modulate response to treatment. TC-PTP / PTPN2 is an enzyme that is essential for the proper functioning of the immune system and that participates in the control of cell proliferation, and inflammation.TC-PTP / PTPN2 was identified as a negative regulator of NUP214-ABL1 kinase activity.

Synonym: PTP2, PTPN2, PTPTPTN2, TCELLPTP, TCPTP, TC-PTP

Molecular Weight: 37.4 kDa

UniProt: P17706

Pathways: EGFR Signaling Pathway, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling