RAC2 Protein (His tag)
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- Target See all RAC2 Proteins
- RAC2 (Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2) (RAC2))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This RAC2 protein is labelled with His tag.
- Purpose
- Recombinant Human RAC2 Protein (His Tag)
- Sequence
- Met 1-Cys 189
- Characteristics
- A DNA sequence encoding the human RAC2 (P15153) (Met 1-Cys 189) was expressed, with a polyhistidine tag at the N-terminus.
- Purity
- > 94 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product RAC2 Protein
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Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2) (RAC2) (AA 1-192) protein (GST tag)
RAC2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2) (RAC2) (AA 1-192) protein (GST tag)RAC2 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % by SDS - PAGE SDS
Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2) (RAC2) (AA 1-189) protein (His tag)Crystallography grade RAC2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2) (RAC2) (AA 1-189) protein (His tag)Crystallography grade RAC2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, 20 % glycerol, pH 7.5
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- RAC2 (Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2) (RAC2))
- Alternative Name
- RAC2 (RAC2 Products)
- Synonyms
- rac2 Protein, AI323801 Protein, AI452260 Protein, EN-7 Protein, Gx Protein, HSPC022 Protein, p21-Rac2 Protein, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) Protein, RAS-related C3 botulinum substrate 2 Protein, Rac family small GTPase 2 Protein, rac2 Protein, Rac2 Protein, RAC2 Protein
- Background
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Background: Ras-related C3 botulinum toxin substrate 2 (Rac2) is a small G-protein belonging to the Ras subfamily of the GTPase family. Rac2 acts as an "on / off" switch for signal transduction cascades and motilities. When GDP is attached to the small G-protein, the enzyme is inactivated. Release of the GDP and replace of the GTP cativate the GTPasee. Rac2 remains active until the GTP is hydrolyzed to GDP. Rac2 is a hematopoietic-specific Rho family GTPase implicated as an important constituent of the NADPH oxidase complex and shares 92% amino acid identity with the ubiquitously expressed Rac1. The small G-protein Rac2 regulates the rearrangements of actin and membrane necessary for Fcy receptor-mediated phagocytosis by macrophages. Activated Rac2 binds to the p21-binding domain of PAK1 and this binding provided a basis for microscopic methods to localize activation of these G proteins inside cells.
Synonym: EN-7;Gx;HSPC022;p21-Rac2
- Molecular Weight
- 22.6 kDa
- UniProt
- P15153
- Pathways
- RTK Signaling, VEGF Signaling
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