S100A1 Protein (Fc Tag)

Catalog No. ABIN7317983

Product Details

Target: S100A1 (S100 Calcium Binding Protein A1 (S100A1))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This S100A1 protein is labelled with Fc Tag.

Purpose: Recombinant Human S100A1 Protein (Fc Tag)(Active)

Sequence: Gly 2-Ser94

Characteristics: A DNA sequence encoding the human S100A1 (NP_006262.1) (Gly 2-Ser94) was expressed with the N-terminal fused Fc region of human IgG1.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its ability to bind biotinylated Human Fc-S100B in functional Elisa.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 100 mM Glycine, 10 mM NaCl, 50 mM Tris, pH 7.5

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: S100A1 (S100 Calcium Binding Protein A1 (S100A1))

Alternative Name: S100A1 (S100A1 Products)

Synonyms: S100 Protein, S100-alpha Protein, S100A Protein, S100A1 Protein, DKFZp468K0511 Protein, AI266795 Protein, S100a Protein, S100 calcium binding protein A1 Protein, S100A1 Protein, S100a1 Protein, s100a1 Protein

Background:

Background: S100A1 is a Ca2+binding protein of the EF-hand type that belongs to the S100 protein family. S100 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation.This protein has been shown to function in the processes including stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of PKC-mediated phosphorylation.. Phosphoglucomutase is a target protein whose activity is antagonistically regulated by S100A1, and recently, S100A1 is also identified as a potent molecular chaperone and a new member of the Hsp70/Hsp90 multichaperone complex. S100A1 displays a tissue-specific expression pattern with highest levels in myocardium and is considered to be an important regulator of cardiac contractility. Accordingly, reduced expression or mutations of S100A1 gene have been implicated in cardiomyopathies.

Synonym: S100,S100-alpha,S100A

Molecular Weight: 37.1 kDa

NCBI Accession: NP_006262

Pathways: Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades, S100 Proteins