S100A11 Protein (His tag)
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- Target See all S100A11 Proteins
- S100A11 (S100 Calcium Binding Protein A11 (S100A11))
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This S100A11 protein is labelled with His tag.
- Purpose
- Recombinant Mouse S100A11 Protein (His Tag)
- Sequence
- Met1-Ile98
- Characteristics
- A DNA sequence encoding the mouse S100A11 (NP_058020.1) (Met1-Ile98) was expressed with a polyhistidine tag at the N-terminus.
- Purity
- > 90 % as determined by SDS-PAGE
- Top Product
- Discover our top product S100A11 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, 10 % glycerol, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- S100A11 (S100 Calcium Binding Protein A11 (S100A11))
- Alternative Name
- S100A11 (S100A11 Products)
- Synonyms
- MLN70 Protein, S100C Protein, PCALG Protein, EMAPI Protein, Emap1 Protein, S100a14 Protein, S100c Protein, cal Protein, S100 calcium binding protein A11 Protein, S100A11 Protein, S100a11 Protein
- Background
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Background: Protein S100-A11, also known as S100 calcium-binding protein A11, S100A11 and MLN70, is a member of the S-100 family. S100A11 is widely expressed in multiple tissues, and is located in cytoplasm, nucleus, and even cell periphery. S100A11 exists as a non-covalent homodimer with an antiparallel conformation. Ca(2+) binding to S100A11 would trigger conformational changes which would expose the hydrophobic cleft of S100A11 and facilitate its interaction with target proteins. As a dual cell growth mediator, S100A11 acts as either a tumor suppressor or promoter in many different types of tumors and would play respective roles in influencing the proliferation of the cancer cells. In the nucleus, S100A11 suppresses the growth of keratinocytes through p21 (CIP1/WAF1) activation and induces cell differentiation. S100A11 is also a novel diagnostic marker in breast carcinoma.
Synonym: Protein S100-A11; Calgizzarin; Endothelial monocyte-activating polypeptide; EMAP; Protein S100-C; S100 calcium-binding protein A11; S100a11; S100c;cal;Emap1;EMAPI;S100A11;S100a14;S100c
- Molecular Weight
- 13.2 kDa
- NCBI Accession
- NP_058020
- Pathways
- S100 Proteins
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