SPINK4 Protein (His tag)

Catalog No. ABIN7197926

Product Details

Target: SPINK4 (Serine Peptidase Inhibitor, Kazal Type 4 (SPINK4))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This SPINK4 protein is labelled with His tag.

Purpose: Recombinant Human SPINK4 Protein (His Tag)

Sequence: Met 1-Cys 86

Characteristics: A DNA sequence encoding the human SPINK4 (NP_055286.1) (Met 1-Cys 86) was expressed, fused with a polyhistidine tag at the C-terminus.

Purity: > 97 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: SPINK4 (Serine Peptidase Inhibitor, Kazal Type 4 (SPINK4))

Alternative Name: SPINK4 (SPINK4 Products)

Synonyms: PEC-60 Protein, PEC60 Protein, MPGC60 Protein, serine peptidase inhibitor, Kazal type 4 Protein, SPINK4 Protein, Spink4 Protein

Background:

Background: Serine protease inhibitor Kazal-type 4, also known as Peptide PEC-60 homolog and SPINK4, is a secreted protein which contains one Kazal-like domain. SPINK4 is a member of the SPINK protein family. The gene family of serine protease inhibitors of the Kazal type (SPINK) are functional and positional candidate genes for celiac disease (CD). SPINK1 plays an important role in protecting the pancreas against excessive trypsinogen activation. It is a potent natural inhibitor of pancreatic trypsin activity. SPINK1 mutations are associated with the development of acute and chronic pancreatitis and have been detected in all forms of chronic pancreatitis. SPINK2 functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges. SPINK9 was identified in human skin. Its expression was strong in palmar epidermis, but not detectable or very low in non palmoplantar skin.

Synonym: Serine Protease Inhibitor Kazal-Type 4, Peptide PEC-60 Homolog, SPINK4,HEL136,MGC133107,PEC-60,PEC60

Molecular Weight: 8 kDa

NCBI Accession: NP_055286