SIRPb2 Protein (Fc Tag)
-
- Target See all SIRPb2 products
- SIRPb2 (Signal-Regulatory Protein beta 2 (SIRPb2))
- Protein Type
- Recombinant
- Origin
- Human
-
Source
- Human Cells
- Purification tag / Conjugate
- This SIRPb2 protein is labelled with Fc Tag.
- Purpose
- Recombinant Human SIRPB2 (C-Fc)
- Sequence
- Gln33-Gly287
- Characteristics
- Recombinant Human Signal-regulatory Protein Beta-2 is produced by our Mammalian expression system and the target gene encoding Gln33-Gly287 is expressed with a Fc tag at the C-terminus.
- Purity
- >95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
-
Signal-Regulatory Protein beta 2 (SIRPb2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)
SIRPb2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- Target
- SIRPb2 (Signal-Regulatory Protein beta 2 (SIRPb2))
- Alternative Name
- SIRPB2 (SIRPb2 Products)
- Synonyms
- PTPN1L Protein, PTPNS1L3 Protein, dJ776F14.2 Protein, SIRPG Protein, SIRPB2 Protein, signal regulatory protein beta 2 Protein, signal-regulatory protein beta-2 Protein, SIRPB2 Protein, LOC100146829 Protein
- Background
-
Background: Signal-regulatory protein beta-2(SIRP-beta-2), is a monomeric single pass type I membrane glycoprotein, belongs to the SIRP/SHPS (CD172) family of the immunoglobulin (Ig) superfamily. The SIRP family are paired receptors that have similar extracellular domains but differing C-terminal domains and functions. A positively charged residue within the transmembrane domain, in analogy to SIRP-beta-1, is implicated to mediate interaction with the adaptor DAP12 protein, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) . Proteins in the SIRP family are typically expressed in immune cells, especially in the myeloid lineages . Based on expression patterns, SIRPs are thought to have roles in immune regulation. SIRP family members role in innate immunity and host defense has potential significance as a therapeutic target in cancer and inflammation. There are currently no known mouse or rat homologs for this protein.
Synonym: dJ776F14.2, PTPN1L, PTPNS1L3, Signal-Regulatory Protein Beta 2, Signal-Regulatory Protein Beta-2, SIRP beta 2, SIRP-beta-2, SIRPG
- Molecular Weight
- 55.2 kDa
- UniProt
- Q5JXA9
-
