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SULT1A3 Protein (His tag)

SULT1A3 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 94 % as determined by reducing SDS-PAGE. Active
Catalog No. ABIN7317564
  • Target See all SULT1A3 Proteins
    SULT1A3 (Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 3 (SULT1A3))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    Human
    Source
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This SULT1A3 protein is labelled with His tag.
    Purpose
    Recombinant Human SULT1A3 Protein (His Tag)(Active)
    Sequence
    Glu2-Leu295
    Characteristics
    A DNA sequence encoding the mature form of human SULT1A3 (NP_808220.1) (Glu2-Leu295) was expressed with a polyhistide tag at the N-terminus.
    Purity
    > 94 % as determined by reducing SDS-PAGE.
    Biological Activity Comment
    Measured by its ability to transfer sulfate from PAPS to 1-Napthol.The specific activity is > 150 pmoles/min/μg.
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  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    SULT1A3 (Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 3 (SULT1A3))
    Alternative Name
    SULT1A3 (SULT1A3 Products)
    Synonyms
    ASTIV Protein, Mx-ST Protein, PST-1 Protein, St1a1 Protein, Stm Protein, Stp1 Protein, Sult1a3 Protein, SULT1A3 Protein, sulfotransferase family 1A member 1 Protein, sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 Protein, Sult1a1 Protein, SULT1A4 Protein
    Background

    Background: SULT1A3 belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. They are different in their tissue distributions and substrate specificities while their gene structure (number and length of exons) is similar. SULT1A3 gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16, this gene and SULT1A4 arose from a segmental duplication. It is the most centromeric of the four sulfotransferase genes. Exons of this gene overlap with exons of a gene that encodes a protein containing GIY-YIG domains (GIYD1). SULT1A3 is expressed in liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte. SULT1A3 is a sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.

    Synonym: Sulfotransferase 1A3/1A4, ST1A3/ST1A4, Aryl Sulfotransferase 1A3/1A4, Catecholamine-Sulfating Phenol Sulfotransferase, HAST3, M-PST, Monoamine-Sulfating Phenol Sulfotransferase, Placental Estrogen Sulfotransferase, Sulfotransferase Monoamine-Preferring, Thermolabile Phenol Sulfotransferase, TL-PST, SULT1A3, STM, SULT1A4,HAST,HAST3,M-PST,ST1A5,STM

    Molecular Weight
    30.5 kDa
    NCBI Accession
    NP_808220
    Pathways
    ER-Nucleus Signaling
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