TXNRD1 Protein (AA 161-647) (His tag)

Catalog No. ABIN7198225

Product Details

Target: TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))

Protein Type: Recombinant

Protein Characteristics: AA 161-647

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This TXNRD1 protein is labelled with His tag.

Purpose: Recombinant Human TXNRD1/TRXR1 Protein (aa 161-647, His Tag)

Sequence: Tyr 161-Cys 647

Characteristics: A DNA sequence encoding the human TXNRD1 isoform 1 (Q16881-1) (Tyr 161-Cys 647) was expressed, with a polyhistide tag at the N-terminus.

Purity: > 90 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))

Alternative Name: TXNRD1/TRXR1 (TXNRD1 Products)

Synonyms: TrxR1 Protein, cb682 Protein, fb83a08 Protein, wu:fb83a08 Protein, GB14972 Protein, MGC85342 Protein, NADPH-dependent thioredoxin reductase C Protein, T32G6.20 Protein, T32G6_20 Protein, GRIM-12 Protein, TR Protein, TR1 Protein, TRXR1 Protein, TXNR Protein, Tr Protein, thioredoxin reductase 1 Protein, thioredoxin reductase 1 L homeolog Protein, NADPH-dependent thioredoxin reductase C Protein, ThioRedoXin Reductase Protein, TXNRD1 Protein, txnrd1 Protein, Trxr-1 Protein, txnrd1.L Protein, NTRC Protein, trxr-1 Protein, Txnrd1 Protein

Background:

Background: Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor the development of Drug-induced liver injury (DILI), which is the most common adverse drug reaction.

Synonym: GRIM-12,TR,TR1,TRXR1,TXNR

Molecular Weight: 55 kDa

Pathways: Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Cell RedoxHomeostasis