DcR1 Protein (His tag)
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- Target See all DcR1 (TNFRSF10C) Proteins
- DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This DcR1 protein is labelled with His tag.
- Purpose
- Recombinant Human TRAIL R3/TNFRSF10C Protein (His Tag)(Active)
- Sequence
- Ala26-Ala221
- Characteristics
- Recombinant Human TNF-Related Apoptosis-Inducing Ligand Receptor 3 is produced by our Mammalian expression system and the target gene encoding Ala26-Ala221 is expressed with a 6His tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L-929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 0.56 ng/ml.
- Top Product
- Discover our top product TNFRSF10C Protein
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Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C) (AA 24-236) protein (His tag)
TNFRSF10C Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C) (AA 1-259) protein (GST tag)TNFRSF10C Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C) (AA 26-236) protein (His tag)Crystallography grade TNFRSF10C Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C) proteinTNFRSF10C Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))
- Alternative Name
- TRAIL R3/TNFRSF10C (TNFRSF10C Products)
- Synonyms
- CD263 Protein, DCR1 Protein, DCR1-TNFR Protein, LIT Protein, TRAIL-R3 Protein, TRAILR3 Protein, TRID Protein, TNFRSF10C Protein, TNF receptor superfamily member 10c Protein, TNFRSF10C Protein
- Background
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Background: Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains, lacks the intracellular signaling domain. As a result, binding of TRAIL to TRAIL R3 doesn't transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.
Synonym: Tumor Necrosis Factor Receptor Superfamily Member 10C, Antagonist Decoy Receptor for TRAIL/Apo-2L, Decoy TRAIL Receptor Without Death Domain, Decoy Receptor 1, DcR1, Lymphocyte Inhibitor of TRAIL, TNF-Related Apoptosis-Inducing Ligand Receptor 3, TRAIL Receptor 3, TRAIL-R3, TRAIL Receptor Without an Intracellular Domain, CD263, TNFRSF10C, DCR1, LIT, TRAILR3, TRID
- Molecular Weight
- 21.8 kDa
- UniProt
- O14798
- Pathways
- Apoptosis
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