DcR1 Protein (AA 24-236) (His tag)
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- Target See all DcR1 (TNFRSF10C) Proteins
- DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 24-236
- Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This DcR1 protein is labelled with His tag.
- Purpose
- Human DcR1/TRAILR3 Protein
- Sequence
- Tyr24-Ala236
- Characteristics
- Recombinant Human DcR1/TRAILR3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Tyr24-Ala236.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- The affinity constant of 0.57 nM as determined in SPR assay (Biacore T200). See testing image for detail.
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Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C) (AA 1-259) protein (GST tag)
TNFRSF10C Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C) (AA 26-236) protein (His tag)Crystallography grade TNFRSF10C Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C) proteinTNFRSF10C Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))
- Alternative Name
- DcR1 (TNFRSF10C Products)
- Synonyms
- CD263 Protein, DCR1 Protein, DCR1-TNFR Protein, LIT Protein, TRAIL-R3 Protein, TRAILR3 Protein, TRID Protein, TNFRSF10C Protein, TNF receptor superfamily member 10c Protein, TNFRSF10C Protein
- Background
- The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family, which mediates apoptosis by the extrinsic pathway. Up-regulation of decoy receptors, DcR1 and DcR2, may result in diminished binding of TRAIL to their functional receptors. DcR1 expression occurs in a subset of EC and may contribute to resistance to TRAIL-induced apoptosis.
- Molecular Weight
- 23.5 kDa. Due to glycosylation, the protein migrates to 60-80 kDa based on Tris-Bis PAGE result.
- UniProt
- Q05D71
- Pathways
- Apoptosis
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