TNFRSF21 Protein (His tag)

Catalog No. ABIN7320343

Product Details

Target: TNFRSF21 (Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21))

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This TNFRSF21 protein is labelled with His tag.

Purpose: Recombinant Mouse DR6/TNFRSF21 Protein (His Tag)(Active)

Sequence: Met 1-His 349

Characteristics: A DNA sequence encoding the mouse TNFRSF21 (NP_055267.1) extracellular domain (Met 1-His 349) was fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Immobilized mouse TNFRSF21-His at 10 μg/ml (100 μl/well) can bind biotinylated human APP-Fc with a linear range of 0.31-5 μg/ml.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: TNFRSF21 (Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21))

Alternative Name: DR6/TNFRSF21 (TNFRSF21 Products)

Synonyms: TNFRSF21 Protein, tnfrsf21 Protein, MGC146356 Protein, BM-018 Protein, CD358 Protein, DR6 Protein, AA959878 Protein, R74815 Protein, TR7 Protein, dr6 Protein, im:6795346 Protein, wu:fa55e01 Protein, wu:fb02e11 Protein, wu:fc29a09 Protein, wu:fi27h08 Protein, TNF receptor superfamily member 21 Protein, tumor necrosis factor receptor superfamily member 21 Protein, tumor necrosis factor receptor superfamily, member 21 Protein, TNFRSF21 Protein, tnfrsf21 Protein, Tnfrsf21 Protein

Background:

Background: TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations.

Synonym: AA959878 Protein, DR6 Protein, R74815 Protein, TR7 Protein

Molecular Weight: 35 kDa

NCBI Accession: NP_055267

Pathways: Regulation of Lipid Metabolism by PPARalpha