TNFRSF6B Protein (AA 24-300) (Fc Tag)

Catalog No. ABIN6253317

Product Details

Target: TNFRSF6B (Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy (TNFRSF6B))

Protein Type: Recombinant

Protein Characteristics: AA 24-300

Origin: Human

Source: CHO Cells

Purification tag / Conjugate: This TNFRSF6B protein is labelled with Fc Tag.

Purpose: DcR3 (human):Fc (human) (rec.)

Specificity: The extracellular domain of human DcR3 (aa 24-300) is fused to the N-terminus of the Fc region of human IgG1.

Characteristics: Protein. The extracellular domain of human DcR3 (aa 24-300) is fused to the N-terminus of the Fc region of human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Decoy receptor 3 (DcR3, TNFRSF6B, M68) is a member of the TNF receptor superfamily. DcR3 shares sequence identity with OPG (31 %), TNF-RII (29 %) and Fas (17 %) and is expressed in a variety of different tissues and at high levels in many malignant tumors. Ligands of DcR3 include Fas ligand, homologous to lymphotoxin showing inducible expression and competing with HSV glycoprotein D for herpes virus entry mediator (a receptor expressed by T lymphocytes), TNF-like molecule 1A and heparan sulfate proteoglycans. DcR3 modulates the function of T cells, dendritic cells and macrophages. DcR3/Fc fusion proteins can bind to human and mouse B cells and suppress the activation of B cells.

Purity: >98 % (SDS-PAGE)

Endotoxin Level: <0.06EU/μg protein (LAL test, Lonza).

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Handling Advice: Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Target Details

Target: TNFRSF6B (Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy (TNFRSF6B))

Alternative Name: DcR3 (TNFRSF6B Products)

Synonyms: DCR3 Protein, DJ583P15.1.1 Protein, M68 Protein, M68E Protein, TR6 Protein, dcr3 Protein, m68 Protein, tr6 Protein, TNF receptor superfamily member 6b Protein, tumor necrosis factor receptor superfamily, member 11b Protein, regulator of telomere elongation helicase 1 Protein, TNF receptor superfamily member 6b L homeolog Protein, TNFRSF6B Protein, tnfrsf11b Protein, RTEL1 Protein, tnfrsf6b Protein, tnfrsf6b.L Protein

Background:

Alternate Names/Synonyms: Decoy Receptor 3, Tumor Necrosis Factor Receptor Superfamily Member 6B, TNFRSF6B, M68

Product Description: Decoy receptor 3 (DcR3, TNFRSF6B, M68) is a member of the TNF receptor superfamily. DcR3 shares sequence identity with OPG (31 % ), TNF-RII (29 %) and Fas (17 %) and is expressed in a variety of different tissues and at high levels in many malignant tumors. Ligands of DcR3 include Fas ligand, homologous to lymphotoxin showing inducible expression and competing with HSV glycoprotein D for herpes virus entry mediator (a receptor expressed by T lymphocytes), TNF-like molecule 1A and heparan sulfate proteoglycans. DcR3 modulates the function of T cells, dendritic cells and macrophages. DcR3/Fc fusion proteins can bind to human and mouse B cells and suppress the activation of B cells.

UniProt: O95407