VWC2 Protein (His tag)

Catalog No. ABIN7317423

Product Details

Target: VWC2 (Von Willebrand Factor C Domain Containing 2 (VWC2))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This VWC2 protein is labelled with His tag.

Purpose: Recombinant Human VWC2/Brorin Protein (His Tag)

Sequence: Met 1-Met 325

Characteristics: A DNA sequence encoding the human VWC2 (NP_940972.2) (Met 1-Met 325) was expressed, fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: VWC2 (Von Willebrand Factor C Domain Containing 2 (VWC2))

Alternative Name: VWC2/Brorin (VWC2 Products)

Synonyms: si:dkey-4j1.1 Protein, PSST739 Protein, UNQ739 Protein, A930041G11Rik Protein, G11 Protein, cradin Protein, von Willebrand factor C domain containing 2 Protein, VWC2 Protein, vwc2 Protein, Vwc2 Protein

Background:

Background: Brorin; also known as brain-specific chordin-like protein; von Willebrand factor C domain-containing protein 2 and VWC2; is a secreted protein which contains two VWFC domains. VWC2 / Brorin is a BMP antagonist which may play a role in neural development. It promotes cell adhesion. VWC2 / Brorin is a unique member of the chordin family. It inhibited the activity of bone morphogenetic protein 2 (BMP2) and BMP6 in mouse preosteoblastic MC3T3-E1 cells. Mouse Brorin was predominantly expressed in neural tissues in embryos and also predominantly expressed in the adult brain. In the brain; the expression was detected in neurons; but not glial cells. The neural tissue-specific expression profile of Brorin is quite distinct from that of any other member of the Chordin family. VWC2 / Brorin protein promoted neurogenesis; but not astrogenesis; in mouse neural precursor cells. VWC2 / Brorin is a novel secreted BMP antagonist that potentially plays roles in neural development and functions.

Synonym: PSST739;UNQ739

Molecular Weight: 34.1 kDa

NCBI Accession: NP_940972