ARHGEF5 Protein (His tag)

Catalog No. ABIN7317679

Product Details

Target: ARHGEF5 (rho Guanine Nucleotide Exchange Factor (GEF) 5 (ARHGEF5))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This ARHGEF5 protein is labelled with His tag.

Purpose: Recombinant Human TIM1/HACVR1 Protein (His Tag)

Sequence: Ser 21-Gly 290

Characteristics: A DNA sequence encoding the mature form of human KIM1 extracellular domain (AAC39862.1) (Ser 21-Gly 290) was fused with a polyhistidine tag at the N-terminus.

Purity: > 93 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Comment:

80-100 kDa

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: ARHGEF5 (rho Guanine Nucleotide Exchange Factor (GEF) 5 (ARHGEF5))

Alternative Name: TIM1 (ARHGEF5 Products)

Synonyms: ARHGEF5 Protein, GEF5 Protein, P60 Protein, TIM Protein, TIM1 Protein, 2210412D05Rik Protein, AA717842 Protein, AW495314 Protein, Tim1 Protein, Rho guanine nucleotide exchange factor 5 Protein, rho guanine nucleotide exchange factor 5 Protein, Rho guanine nucleotide exchange factor (GEF) 5 Protein, ARHGEF5 Protein, LOC100414419 Protein, Arhgef5 Protein

Background:

Background: HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type â…  integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.

Synonym: CD365;HACVR;HAVCR;HAVCR-1;KIM-1;KIM1;TIM;TIM-1;TIM1;TIMD-1;TIMD1

Molecular Weight: 31.3 kDa