FZD8 Protein (Biotin,His-Avi Tag)
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- Target See all FZD8 Proteins
- FZD8 (Frizzled Family Receptor 8 (FZD8))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This FZD8 protein is labelled with Biotin,His-Avi Tag.
- Purpose
- Recombinant Human Frizzled-8 (C-6His-Avi) Biotinylated
- Sequence
- Ala28-Pro172
- Characteristics
- Biotinylated Recombinant Human Frizzled-8 is produced by our Mammalian expression system and the target gene encoding Ala28-Pro172 is expressed with a 6His, Avi tag at the C-terminus.
- Purity
- >95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product FZD8 Protein
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Frizzled Family Receptor 8 (FZD8) (AA 72-161) protein (GST tag)
FZD8 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Frizzled Family Receptor 8 (FZD8) protein (His tag)FZD8 Origin: Human Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
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- Comment
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25-35 kDa
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- FZD8 (Frizzled Family Receptor 8 (FZD8))
- Alternative Name
- Frizzled-8 (FZD8 Products)
- Synonyms
- FZ-8 Protein, hFZ8 Protein, FZD8 Protein, Fz-8 Protein, frizzled8 Protein, xfz8 Protein, Xfz8 Protein, frizzled-8 Protein, hfz8 Protein, Fz8 Protein, fzd8 Protein, fz5 Protein, fz8a Protein, fzc Protein, wu:fd02c05 Protein, zg05 Protein, ZG06 Protein, Zfz8b Protein, fz6 Protein, fz8b Protein, fzA Protein, ik:tdsubc_1e1 Protein, xx:tdsubc_1e1 Protein, zfzA Protein, frizzled class receptor 8 Protein, frizzled class receptor 8 S homeolog Protein, frizzled class receptor 8 L homeolog Protein, frizzled class receptor 8a Protein, frizzled class receptor 8b Protein, FZD8 Protein, fzd8.S Protein, fzd8 Protein, Fzd8 Protein, fzd8.L Protein, fzd8a Protein, fzd8b Protein
- Background
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Background: Frizzled-8 is one of at least ten seven-transmembrane (7TM) glycoproteins of the Frizzled family of Wnt receptors. Frizzled proteins are thought to be G-protein-coupled. Wnt engagement, with low density lipoprotein receptor-related proteins LRP-5 or LRP-6 acting as co-receptors, stabilizes beta -catenin and promotes gene transcription that is important in development and tissue maintenance. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. These ligands bind the extracellular CRD of Frizzled-8, blocking Wnt binding. The recombinant Frizzled-8 CRD has also been used to block Wnt signaling and inhibit growth of teratocarcinomas.
Synonym: frizzled 8, frizzled family receptor 8, Frizzled8, Frizzled-8, FZ-8, FZD8, hFZ8
- Molecular Weight
- 19.1 kDa
- UniProt
- Q9H461
- Pathways
- WNT Signaling
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