IgG1 Protein (Cys103Ser-Mutant, Leu117Phe-Mutant, Leu118Glu-Mutant, Pro214Ser-Mutant) (His tag)

Catalog No. ABIN7271665

Product Details

Target: IgG1

Protein Type: Recombinant

Protein Characteristics: Cys103Ser-Mutant, Leu117Phe-Mutant, Leu118Glu-Mutant, Pro214Ser-Mutant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This IgG1 protein is labelled with His tag.

Purpose: Human IgG1 Fc (C103S, L117F, L118E, P214S) Protein, His Tag

Sequence: Glu 99 - Lys 330

Characteristics: Human IgG1 Fc (C103S, L117F, L118E, P214S), His Tag (IG1-H52H9) is expressed from human 293 cells (HEK293). It contains AA Glu 99 - Lys 330 (Accession # P01857-1 (C103S, L117F, L118E, P214S).

Purity: >95 % as determined by SDS-PAGE.

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Application Notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28 kDa. The protein migrates as 30-33 kDa under reducing (R) condition due to glycosylation.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Storage: -20 °C

Storage Comment: -20°C

Target Details

Target: IgG1

Abstract: IgG1 Products

Synonyms: IgG1 Protein, Igh-4 Protein, VH7183 Protein, immunoglobulin heavy constant gamma 1 (G1m marker) Protein, Ighg1 Protein

Target Type: Antibody

Background: Synonyms:IgG1,Description:Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). IgG1 Fc was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases.

Molecular Weight: 28 kDa