FAM3D Protein (AA 26-224) (Fc Tag)

Catalog No. ABIN7274578

Product Details

Target: FAM3D (Family with Sequence Similarity 3, Member D (FAM3D))

Protein Type: Recombinant

Protein Characteristics: AA 26-224

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This FAM3D protein is labelled with Fc Tag.

Purpose: Human FAM3D Protein

Sequence: Tyr26-Phe224

Characteristics: Recombinant Human FAM3D Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Tyr26-Phe224.

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: FAM3D (Family with Sequence Similarity 3, Member D (FAM3D))

Alternative Name: FAM3D (FAM3D Products)

Synonyms: Oit1 Protein, EF7 Protein, OIT1 Protein, 2310076N21Rik Protein, AV067083 Protein, EF-7 Protein, Fam3d Protein, family with sequence similarity 3, member D Protein, family with sequence similarity 3 member D Protein, oncoprotein induced transcript 1 Protein, Fam3d Protein, FAM3D Protein, Oit1 Protein

Background: The physiological homeostasis of gut mucosal barrier is maintained by both genetic and environmental factors and its impairment leads to pathogenesis such as inflammatory bowel disease. A cytokine like molecule, FAM3D (mouse Fam3D), is highly expressed in mouse gastrointestinal tract. Here, we demonstrate that deficiency in Fam3D is associated with impaired integrity of colonic mucosa, increased epithelial hyper-proliferation, reduced anti-microbial peptide production and increased sensitivity to chemically induced colitis associated with high incidence of cancer.

Molecular Weight: 48.7 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.

UniProt: Q96BQ1