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Fc gamma RII (CD32) (AA 17-208) protein (His tag)

CD32 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Catalog No. ABIN7274645
  • Target See all Fc gamma RII (CD32) Proteins
    Fc gamma RII (CD32)
    Protein Type
    Recombinant
    Protein Characteristics
    AA 17-208
    Origin
    • 3
    • 2
    • 2
    • 1
    • 1
    Cynomolgus
    Source
    • 5
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    His tag
    Purpose
    Cynomolgus Fc gamma RIII/CD16 Protein
    Sequence
    Gly17-Gln208
    Characteristics
    Recombinant Cynomolgus Fc gamma RIII/CD16 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly17-Gln208.
    Purity
    > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
    Sterility
    0.22 μm filtered
    Endotoxin Level
    Less than 1EU per μg by the LAL method.
    Biological Activity Comment
    The affinity constant of 0.251 μM as determined in SPR assay (Biacore T200). See testing image for detail.
    Top Product
    Discover our top product CD32 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
    Buffer
    Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
    Storage
    -20 °C,-80 °C
    Storage Comment
    -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    Fc gamma RII (CD32)
    Alternative Name
    Fc gamma RIII (CD32 Products)
    Synonyms
    CD32 Protein, CD32B Protein, FCG2 Protein, FCGR2 Protein, IGFR2 Protein, FCGR2B Protein, AI528646 Protein, F630109E10Rik Protein, Fc[g]RII Protein, FcgRII Protein, Fcgr2 Protein, Fcgr2a Protein, Fcr-2 Protein, Fcr-3 Protein, Ly-17 Protein, Ly-m20 Protein, LyM-1 Protein, Lym-1 Protein, FCRII Protein, FcRII Protein, Fc fragment of IgG receptor IIb Protein, Fc receptor, IgG, low affinity IIb Protein, FCGR2B Protein, Fcgr2b Protein
    Background
    Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for human Fc gamma RI, Fc gamma RIIA, Fc gamma RIIB, Fc gamma RIIIA, and FcRn receptors has been determined.A common set of IgG1 residues is involved in binding to all Fc gamma R, Fc gamma RII and Fc gamma RIII also utilize residues outside this common set.
    Molecular Weight
    23.1 kDa. Due to glycosylation, the protein migrates to 45-55 kDa based on Tris-Bis PAGE result.
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