HLA-G Free Heavy Chain (AA 25-305) protein (His-Avi Tag)
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 95 % as determined by Tris-Bis PAGE
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- Target
- HLA-G Free Heavy Chain
- Protein Type
- Recombinant
- Protein Characteristics
- AA 25-305
- Origin
- Human
- Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- His-Avi Tag
- Purpose
- Human HLA-G Free Heavy Chain Protein
- Sequence
- Gly25-Thr305 (C66S)
- Characteristics
- Recombinant Human HLA-G Free Heavy Chain Protein is expressed from E.coli with His tag and Avi tag at the C-Terminus.It contains Gly25-Thr305(C66S).
- Purity
- > 95 % as determined by Tris-Bis PAGE
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Supplied as 0.22μm filtered solution in 20 mM Tris, 500 mM NaCl, 20 % Glycerol ( pH 8.0).
- Storage
- -80 °C
- Storage Comment
- Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- HLA-G Free Heavy Chain
- Background
- HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. The first functional finding constituted the basis for HLA-G research and can be summarized as such: HLA-G, membrane-bound or soluble, strongly binds its inhibitory receptors on immune cells (NK, T, B, monocytes/dendritic cells), inhibits the functions of these effectors, and so induces immune inhibition.
- Molecular Weight
- 35.5 kDa. The protein migrates to 36-40 kDa based on Tris-Bis PAGE result.
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