IL17C Protein (AA 19-197) (His-Avi Tag)

Catalog No. ABIN7274998

Product Details

Target: IL17C (Interleukin 17C (IL17C))

Protein Type: Recombinant

Protein Characteristics: AA 19-197

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This IL17C protein is labelled with His-Avi Tag.

Purpose: Human IL-17C Protein

Sequence: His19-Val197

Characteristics: Recombinant Human IL-17C Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains His19-Val197.

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by SEC-HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Human IL-17C at 5μg/ml (100μl/Well) on the plate. Dose response curve for Human IL-17R alpha, hFc Tag with the EC50 of 2.6μg/ml determined by ELISA. See testing image for detail.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in 50 mM MES, 150 mM NaCl (PH 6.0).

Buffer: Lyophilized from 0.22μm filtered solution in 50 mM MES, 150 mM NaCl (PH 6.0). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: IL17C (Interleukin 17C (IL17C))

Alternative Name: IL-17C (IL17C Products)

Synonyms: IL17C Protein, il17-3 Protein, CX2 Protein, IL-17C Protein, IL-21 Protein, interleukin 17C Protein, interleukin 17c Protein, IL17C Protein, il17c Protein, Il17c Protein

Background: Interleukin-17C (IL-17C) is a 15-20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. The six IL-17 cytokines (IL-17A-F) are encoded by separate genes but adopt a conserved cystine knot fold. IL-17C is Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G.

Molecular Weight: 22.6 kDa. Due to glycosylation, the protein migrates to 25 kDa based on Tris-Bis PAGE result.

UniProt: Q9P0M4

Pathways: Cellular Response to Molecule of Bacterial Origin