LY9 Protein (AA 48-454) (His-Avi Tag,Biotin)

Catalog No. ABIN7275224

Product Details

Target: LY9 (CD229) (Lymphocyte Antigen 9 (CD229))

Protein Type: Recombinant

Protein Characteristics: AA 48-454

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This LY9 protein is labelled with His-Avi Tag,Biotin.

Purpose: Biotinylated Human CD229/SLAMF3 Protein

Sequence: Lys48-Lys454

Characteristics: Recombinant Biotinylated Human CD229/SLAMF3 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Lys48-Lys454.

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: LY9 (CD229) (Lymphocyte Antigen 9 (CD229))

Alternative Name: CD229 (CD229 Products)

Synonyms: LY9 Protein, CD229 Protein, SLAMF3 Protein, hly9 Protein, mLY9 Protein, AI893573 Protein, Lgp100 Protein, Ly-9 Protein, T100 Protein, lymphocyte antigen 9 Protein, LY9 Protein, Ly9 Protein

Background: CD229 was strongly and homogeneously overexpressed on the PC of patients with monoclonal gammopathy of undetermined significance (MGUS), smoldering myeloma, MM, and PC leukemia. CD229 was particularly overexpressed on those PC showing an abnormal phenotype such as expression of CD56. Most importantly, CD229 was also highly expressed on those cells in the patients' BM displaying the phenotype of chemotherapy-resistant and myeloma-propagating cells.

Molecular Weight: 47.7 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result.

Pathways: BCR Signaling