SEZ6 Protein (AA 20-927) (His tag)
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- Target See all SEZ6 Proteins
- SEZ6 (Seizure Related 6 Homolog (SEZ6))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 20-927
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Origin
- Cynomolgus
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This SEZ6 protein is labelled with His tag.
- Purpose
- Cynomolgus SEZ6 Protein
- Sequence
- Leu20-His927
- Characteristics
- Recombinant Cynomolgus SEZ6 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu20-His927.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Cynomolgus SEZ6, His Tag at 5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 22.7ng/ml determined by ELISA. See testing image for detail.
- Top Product
- Discover our top product SEZ6 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- SEZ6 (Seizure Related 6 Homolog (SEZ6))
- Alternative Name
- SEZ6 (SEZ6 Products)
- Synonyms
- BSRP-C Protein, D11Bhm177e Protein, mKIAA4158 Protein, sez-6 Protein, seizure related gene 6 Protein, seizure related 6 homolog Protein, Sez6 Protein, SEZ6 Protein
- Background
- Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface.
- Molecular Weight
- 99.11 kDa. Due to glycosylation, the protein migrates to 150-180 kDa based on Tris-Bis PAGE result.
- UniProt
- A0A2K5WPJ4
- Pathways
- Synaptic Membrane
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