TMEM106B Protein (AA 119-275) (Fc Tag)
TMEM106B
Origin: Mouse
Host: HEK-293 Cells
Recombinant
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
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- Target See all TMEM106B Proteins
- TMEM106B (Transmembrane Protein 106B (TMEM106B))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 119-275
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This TMEM106B protein is labelled with Fc Tag.
- Purpose
- Mouse TMEM106B Protein
- Sequence
- Pro119-Gln275
- Characteristics
- Recombinant Mouse TMEM106B Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Pro119-Gln275.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- TMEM106B (Transmembrane Protein 106B (TMEM106B))
- Alternative Name
- TMEM106B (TMEM106B Products)
- Synonyms
- 2310036D22Rik Protein, 5830455K21Rik Protein, 6430519M21Rik Protein, AI428776 Protein, AI661344 Protein, LRRGT00101 Protein, MGC81788 Protein, tmem106b Protein, zgc:114147 Protein, zgc:64013 Protein, transmembrane protein 106B Protein, transmembrane protein 106B S homeolog Protein, transmembrane protein 106Bb Protein, transmembrane protein 106b Protein, transmembrane protein 106Ba Protein, TMEM106B Protein, Tmem106b Protein, tmem106b.S Protein, tmem106b Protein, tmem106bb Protein, Tsp_02056 Protein, Tsp_01553 Protein, t106b Protein, tmem106ba Protein
- Background
- TMEM106B is a well-recognised risk factor for FTD caused by GRN mutation. Elegant experiments have suggested that increased risk for FTD is due to elevated levels of TMEM106B (Nicholson et al, 2013, Gallagher et al, 2017). Therefore, recent work has explored the therapeutic potential of reducing TMEM106B levels, with initial results looking encouraging, as crossing a Grn-deficient mouse to a Tmem106b knockout showed a rescue in FTD-related behavioural defects and specific aspects of lysosome dysfunction (Klein et al, 2017).
- Molecular Weight
- 44.8 kDa. Due to glycosylation, the protein migrates to 65-68 kDa based on Tris-Bis PAGE result.
- UniProt
- Q80X71
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