NPR1 Protein (Fc Tag)
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- Target See all NPR1 Proteins
- NPR1 (Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This NPR1 protein is labelled with Fc Tag.
- Purpose
- Recombinant human NPR1 protein with C-terminal human Fc tag
- Specificity
- NPR1 (Gly33-Glu473) hFc (Glu99-Ala330)
- Characteristics
- Extracellular Domain Protein
- Purity
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product NPR1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- NPR1 (Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1))
- Alternative Name
- NPR1 (NPR1 Products)
- Synonyms
- ANPRA Protein, ANPa Protein, GUC2A Protein, GUCY2A Protein, NPRA Protein, Anpra Protein, Gca Protein, NPR-A Protein, Npra Protein, sGC Protein, si:dkey-27c15.1 Protein, AI893888 Protein, GC-A Protein, Pndr Protein, ARABIDOPSIS NONEXPRESSER OF PR GENES 1 Protein, ATNPR1 Protein, F15H21.6 Protein, F15H21_6 Protein, NIM1 Protein, NON-INDUCIBLE IMMUNITY 1 Protein, NONEXPRESSER OF PR GENES 1 Protein, REGULATORY PROTEIN NPR1 Protein, SAI1 Protein, SALICYLIC ACID INSENSITIVE 1 Protein, natriuretic peptide receptor 1 Protein, natriuretic peptide receptor 1a Protein, regulatory protein (NPR1) Protein, NPR1 Protein, Npr1 Protein, npr1a Protein
- Background
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ANP-A, ANPR-A, ANPRA, NPR-A, GC-A
Description: Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides, they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2, MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009] - Molecular Weight
- predicted molecular mass of 75.0 kDa after removal of the signal peptide. The apparent molecular mass of NPR1-hFc is 95-130 kDa due to glycosylation.
- UniProt
- P16066
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